Irina Holodņuka

2023

Association of the prognostic leukemic cell surface markers with the mutation status of the immunoglobulin heavy chain variable region genes in untreated patients with chronic lymphocytic leukemia.

Nazarenko, M., Zvejniece, L., Rivkina, A., Korņilova, O., Svirskis, Š., Gorbačova, V., Pavlova, J., Leončiks, A., Lejniece, S. & Kholodnyuk, I., 30 Aug 2023, In: Medicina (Kaunas). 59, Suppl.2, p. 146 1 p., 146.

Research output: Contribution to journal › Meeting Abstract › peer-review

Open Access

EBV INFECTION AND DISEASE PROGRESSION CELL-SURFACE MARKERS IN LATVIAN COHORT OF UNTREATED PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA

Kholodnyuk, I. (Corresponding Author), Kozireva, S., Rivkina, A., Zvejniece, L., Kornilova, O., Pavlova, J., Murovska, M. & Lejniece, S., 30 Aug 2023, In: Medicina (Kaunas). 59, Suppl. 2, p. 363 1 p.

Research output: Contribution to journal › Meeting Abstract › peer-review

EBV infection promotes migration of the host B cells via up-regulation of the inflammatory chemokine receptors CCR1 and CCR2

Kholodnyuk Holodnuka, I. (Corresponding Author), Kozireva, S., Zvejniece, L., Rudevica, Z., Leonciks, A., Ehlin-Henriksson, B. & Kashuba, E., 2023, p. 43. 1 p.

Research output: Contribution to conference › Abstract › peer-review

Investigation of the Epstein-Barr virus infection in untreated patients with chronic lymphocytic leukemia in Latvia.

Nazarenko, M., Zvejniece, L., Kozireva, S., Korņilova, O., Gorbačova, V., Rivkina, A., Lejniece, S. & Kholodnyuk Holodnuka, I., 11 Sept 2023, p. 76-77. 2 p.

Research output: Contribution to conference › Abstract › peer-review

Open Access

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Mutations within the chemokine receptor CCR2 gene coding region in patients with chronic lymphocytic leukemia

Zvejniece, L., Rudevica, Z., Leonciks, A., Rivkina, A., Lejniece, S. & Holodnuka Kholodnyuk, I., 30 Aug 2023, In: Medicina (Kaunas). 59, Suppl.2, p. 169 1 p., 169.

Research output: Contribution to journal › Meeting Abstract › peer-review

Open Access

The Highest EBV DNA Copy Numbers are Detected in Untreated Patients with the High-Risk Chronic Lymphocytic Leukemia

Kholodnyuk, I., Zvejniece, L., Kozireva, S., Korņilova, O., Nazarenko, M., Rudevica, Z., Leonciks, A., Rivkina, A. & Lejniece, S., Nov 2023, p. 19-20. 2 p.

Research output: Contribution to conference › Abstract › peer-review

Open Access

2022

Expression of the Chemokine Receptor CCR1 in Burkitt Lymphoma Cell Lines Is Linked to the CD10-Negative Cell Phenotype and Co-Expression of the EBV Latent Genes EBNA2, LMP1, and LMP2

Zvejniece, L., Kozireva, S., Rudevica, Z., Leonciks, A., Ehlin-Henriksson, B., Kashuba, E. & Kholodnyuk, I. (Corresponding Author), 22 Mar 2022, In: International Journal of Molecular Sciences. 23, 7, 3434.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Citations (Scopus)

2021

Analysis of the chemokine receptor CCR1 mutations in patients with chronic lymphocytic leukemia

Zvejniece, L., Rivkina, A., Kurbatska, V., Kistkins, S., Pavlova, J., Leončiks, A., Lejniece, S. & Holodņuka, I., 24 Mar 2021, p. 118.

Research output: Contribution to conference › Abstract › peer-review

CHEMOKINE RECEPTORS CCR1 AND CCR2 ARE UP-REGULATED ON CIRCULATING LEUKEMIC CELLS OF THE UNTREATED CD38+ CLL PATIENTS WITH THE HIGH EBV DNA-COPY LOAD

Kholodnyuk, I., Hippe, L., Rivkina, A., Svirskis, S., Sultanova, A., Kozireva, S., Pavlova, J., Murovska, M. & Lejniece, S., 15 Sept 2021, p. 210. 1 p.

Research output: Contribution to conference › Abstract › peer-review

Delivery of oligonucleotide-based therapeutics: challenges and opportunities

Hammond, S. M., Aartsma-Rus, A., Alves, S., Borgos, S. E., Buijsen, R. A. M., Collin, R. W. J., Covello, G., Denti, M. A., Desviat, L. R., Echevarría, L., Foged, C., Gaina, G., Garanto, A., Goyenvalle, A. T., Guzowska, M., Holodnuka, I., Jones, D. R., Krause, S., Lehto, T. & Montolio, M. & 2 others, Van Roon-Mom, W. & Arechavala-Gomeza, V. (Corresponding Author), 9 Apr 2021, In: EMBO Molecular Medicine. 13, 4, e13243.

Research output: Contribution to journal › Review article › peer-review

Open Access

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189 Citations (Scopus)

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EPSTEIN BARR VIRUS INFECTION IN NEWLY DIAGNOSED CD38-POSITIVE AND CD38-NEGATIVE PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA

Kozireva, S., Zvejniece, L., Rivkina, A., Pavlova, J., Murovska, M., Lejniece, S. & Kholodnyuk, I., 15 Sept 2021, p. 218. 1 p.

Research output: Contribution to conference › Abstract › peer-review

Expression of the chemokine receptors CCR1 and CCR2 on the circulating leukemic cells of patients with the high-risk chronic lymphocytic leukemia.

Holodnuka, I., Rivkina, A., Zvejniece, L., Demida, O., Svirskis, S., Kozireva, S., Pavlova, J. & Lejniece, S., 13 Dec 2021, p. P-32. 1 p.

Research output: Contribution to conference › Abstract › peer-review

Inflammatory chemokine receptors in Epstein–Barr virus infection

Holodņuka, I., Kozireva, S., Zvejniece, L., Leonciks, A., Rudevica, Z. & Kashuba, E., 24 Mar 2021, p. 313.

Research output: Contribution to conference › Abstract › peer-review

Prognostic markers of disease progression in untreated patients with chronic lymphocytic leukemia

Rivkina, A., Kholodnuka, I., Zvejniece, L., Svirskis, S., Soloveicika, M., Kozireva, S., Pavlova, J., Leonciks, A. & Lejniece, S., 24 Mar 2021, p. 121.

Research output: Contribution to conference › Abstract › peer-review

2020

Chemokine Receptors CCR1 and CCR2 on Peripheral Blood Mononuclear Cells of Newly Diagnosed Patients with the CD38-Positive Chronic Lymphocytic Leukemia

Kholodnyuk, I. (Corresponding Author), Rivkina, A., Hippe, L., Svirskis, S., Kozireva, S., Ventina, I., Spaka, I., Soloveichika, M., Pavlova, J., Murovska, M. & Lejniece, S., Jul 2020, In: Journal of clinical medicine. 9, 7, p. 1-17 17 p., 2312.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Citations (Scopus)

Expression of the reverse transcriptase domain of telomerase reverse transcriptase induces lytic cellular response in dna-immunized mice and limits tumorigenic and metastatic potential of murine adenocarcinoma 4t1 cells

Jansons, J., Bayurova, E., Skrastina, D., Kurlanda, A., Fridrihsone, I., Kostyushev, D., Kostyusheva, A., Artyuhov, A., Dashinimaev, E., Avdoshina, D., Kondrashova, A., Valuev-Elliston, V., Latyshev, O., Eliseeva, O., Petkov, S., Abakumov, M., Hippe, L., Kholodnyuk, I., Starodubova, E. & Gorodnicheva, T. & 3 others, Ivanov, A., Gordeychuk, I. & Isaguliants, M. (Corresponding Author), 18 Jun 2020, In: Vaccines. 8, 2, p. 1-42 42 p., 318.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Citations (Scopus)

2019

Proportion of the CD19-positive and CD19-negative lymphocytes and monocytes within the peripheral blood mononuclear cell set is characteristic for rheumatoid arthritis

Kholodnyuk, I., Kadisa, A., Svirskis, S., Gravelsina, S., Studers, P., Spaka, I., Sultanova, A., Lejniece, S., Lejnieks, A. & Murovska, M., Oct 2019, In: Medicina (Lithuania). 55, 10, 14 p., 630.

Research output: Contribution to journal › Article › peer-review

Open Access

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9 Citations (Scopus)

12 Downloads (Pure)

2018

Positioning Europe for the EPITRANSCRIPTOMICS challenge

Jantsch, M. F., Quattrone, A., O'Connell, M., Helm, M., Frye, M., Macias-Gonzales, M., Ohman, M., Ameres, S., Willems, L., Fuks, F., Oulas, A., Vanacova, S., Nielsen, H., Bousquet-Antonelli, C., Motorin, Y., Roignant, J. Y., Balatsos, N., Dinnyes, A., Baranov, P. & Kelly, V. & 40 others, Lamm, A., Rechavi, G., Pelizzola, M., Liepins, J., Holodnuka Kholodnyuk, I., Zammit, V., Ayers, D., Drablos, F., Dahl, J. A., Bujnicki, J., Jeronimo, C., Almeida, R., Neagu, M., Costache, M., Bankovic, J., Banovic, B., Kyselovic, J., Valor, L. M., Selbert, S., Pir, P., Demircan, T., Cowling, V., Schäfer, M., Rossmanith, W., Lafontaine, D., David, A., Carre, C., Lyko, F., Schaffrath, R., Schwartz, S., Verdel, A., Klungland, A., Purta, E., Timotijevic, G., Cardona, F., Davalos, A., Ballana, E., O'Carroll, D., Ule, J. & Fray, R., 3 Jun 2018, In: RNA Biology. 15, 6, p. 829-831 3 p.

Research output: Contribution to journal › Comment/debate

Open Access

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18 Citations (Scopus)

11 Downloads (Pure)

Upregulation of the chemokine receptor CCR2B in Epstein-Barr Virus-positive Burkitt lymphoma cell lines with the latency III program

Kozireva, S., Rudevica, Z., Baryshev, M., Leonciks, A., Kashuba, E. & Kholodnyuk, I. (Corresponding Author), 3 May 2018, In: Viruses. 10, 5, 239.

Research output: Contribution to journal › Article › peer-review

Open Access

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5 Citations (Scopus)

20 Downloads (Pure)

2017

Expression of the chemokine receptors CCR1 and CCR2B is up-regulated in peripheral blood B cells upon EBV infection and in established lymphoblastoid cell lines

Kholodnyuk, I., Rudevica, Z., Leonciks, A., Ehlin-Henriksson, B. & Kashuba, E., Dec 2017, In: Virology. 512, p. 1-7 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Citations (Scopus)

Nucleotide-modified RNA-aptamer inhibits in vitro cell-proliferation of Burkitt lymphoma, but not B-cell lymphoblastoid or T-cell lymphoma cell lines

Kholodnyuk, I., Rudevica, Z., Cistjakovs, M., Kozireva, S., Norstedt, G. & Leonciks, A., 24 Jun 2017. 1 p.

Research output: Contribution to conference › Abstract › peer-review

Open Access

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The TGF-beta — smad pathway is inactivated in cronic lymphocytic leukemia cells

Matveeva, A., Kovalevska, L., Kholodnyuk, I., Ivanivskaya, T. & Kashuba, E., Dec 2017, In: Experimental Oncology. 39, 4, p. 286-290 5 p.

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

2016

Whole-Cell SELEX method modification for generation of nucleotide-modified RNA-aptamers to the cell surface: Application in Burkitt lymphoma versus non-malignant lymphoblastoid cells model

Holodnuka, I., Rudevica, Z., Cistjakovs, M., Avotina, D., Leonciks, A., Norstedt, G. & Kholodnyuk, I., Dec 2016, In: European Journal of Cancer. 69, S1, p. S69 197.

Research output: Contribution to journal › Meeting Abstract › peer-review

2015

Peripheral blood lymphocyte phenotype of ZAP-70⁺ and ZAP-70^- Patients with B-cell chronic lymphocytic leukaemia

Rivkina, A., Kholodyuk, I. H., Murovska, M., Soloveichika, M. & Lejniece, S., 1 Mar 2015, In: Experimental Oncology. 37, 1, p. 73-76 4 p.

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

2014

Cell-surface expression of chemokine receptors CCR1 and CCR2 in PB B-lymphocytes of patients with rheumatoid arthritis, osteoarthritis, and B-cell lymphoproliferative disorder

Kholodnyuk, I., Spaka, I., Kadisa, A., Studers, P., Vilkaite, A., Spaks, A., Gravelsina, S., Rivkina, A., Lejniece, S., Lejnieks, A. & Murovska, M., 3 Nov 2014, In: Acta Reumatologica Portuguesa. 39, Suppl. EWIMID, p. 36-37 1 p., P16.

Research output: Contribution to journal › Meeting Abstract › peer-review

Open Access

2013

Overexpression of MRPS18-2 in cancer cell lines results in appearance of multinucleated cells

Shevchuk, Z., Yurchenko, M. Y., Darekar, S. D., Holodnuka-Kholodnyuk, I., Kashuba, V. I. & Kashuba, E. V., 2013, In: Acta Naturae. 5, 16, p. 85-89 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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5 Citations (Scopus)

5 Downloads (Pure)

2007

Mandatory chromosomal segment balance in aneuploid tumor cells

Kost-Alimova, M., Darai-Ramqvist, E., Yau, W. L., Sandlund, A., Fedorova, L., Yang, Y., Kholodnyuk, I., Cheng, Y., Lung, M. L., Stanbridge, E., Klein, G. & Imreh, S., 2007, In: BMC Cancer. 7, 21.

Research output: Contribution to journal › Article › peer-review

Open Access

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4 Citations (Scopus)

8 Downloads (Pure)

2006

Down regulation of 3p genes, LTF, SLC38A3 and DRR1, upon growth of human chromosome 3-mouse fibrosarcoma hybrids in severe combined immunodeficiency mice

Kholodnyuk, I. D., Kozireva, S., Kost-Alimova, M., Kashuba, V., Klein, G. & Imreh, S., 1 Jul 2006, In: International Journal of Cancer. 119, 1, p. 99-107 9 p.

Research output: Contribution to journal › Article › peer-review

44 Citations (Scopus)

2003

Consistent downregulation of human lactoferrin gene, in the common eliminated region 1 on 3p21.3, following tumor growth in severe combined immunodeficient (SCID) mice

Yang, Y., Li, J., Szeles, A., Imreh, M. P., Kost-Alimova, M., Kiss, H., Kholodnyuk, I., Fedorova, L., Darai, E., Klein, G. & Imreh, S., 10 Mar 2003, In: Cancer Letters. 191, 2, p. 155-164 10 p.

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

2002

The microcell hybrid-based "elimination test" identifies a 1-Mb putative tumor-suppressor region at 3p22.2-p22.1 centromeric to the homozygous deletion region detected in lung cancer

Kholodnyuk, I. D., Kost-Alimova, M., Yang, Y., Kiss, H., Fedorova, L., Klein, G. & Imreh, S., 2002, In: Genes Chromosomes and Cancer. 34, 3, p. 341-344 4 p.

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

2001

Similar regions of human chromosome 3 are eliminated from or retained in human/human and human/mouse microcell hybrids during tumor growth in severe combined immunodeficient (SCID) mice

Yang, Y., Kost-Alimova, M., Ingvarsson, S., Qianhui, Q., Kiss, H., Szeles, A., Kholodnyuk, I., Cuthbert, A., Klein, G. & Imreh, S., 30 Jan 2001, In: Proceedings of the National Academy of Sciences of the United States of America. 98, 3, p. 1136-1141 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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29 Citations (Scopus)

13 Downloads (Pure)

2000

A microcell hybrid based approach to identify chromosome 3p genes that antagonize tumor growth

Kholodnyuk, I. D., Szeles, A., Kost-Alimova, M., Kashuba, V., Yang, Y., Klein, G. & Imreh, S., Oct 2000, In: American Journal of Human Genetics. 67, 4, Suppl.2, p. 101 1 p.

Research output: Contribution to journal › Meeting Abstract › peer-review

Inactivation of the human fragile histidine triad gene at 3p14.2 in monochromosomal human/mouse microcell hybrid-derived severe combined immunodeficient mouse tumors

Kholodnyuk, I. D., Szeles, A., Yang, Y., Klein, G. & Imreh, S., 15 Dec 2000, In: Cancer Research. 60, 24, p. 7119-7125 7 p.

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

1999

A 1-MB PAC contig spanning the common eliminated region 1 (CER1) in microcell hybrid-derived SCID tumors

Yang, Y., Kiss, H., Kost-Alimova, M., Kedra, D., Fransson, I., Seroussi, E., Li, J., Szeles, A., Kholodnyuk, I., Imreh, M. P., Fodor, K., Hadlaczky, G., Klein, G., Dumanski, J. P. & Imreh, S., 1 Dec 1999, In: Genomics. 62, 2, p. 147-155 9 p.

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

1997

A 3p21.3 Region is preferentially eliminated from human chromosome 3/house microcell hybrids during tumor growth in SCID mice

Kholodnyuk, I., Kost-Alimova, M., Kashuba, V., Gizatulin, R., Szeles, A., Stanbridge, E. J., Zabarovsky, E. R., Klein, G. & Imreh, S., Mar 1997, In: Genes Chromosomes and Cancer. 18, 3, p. 200-211 12 p.

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Assignment of the ARHA and GPX1 genes to human chromosome bands 3p21.3 by in situ hybridization and with somatic cell hybrids

Kiss, C., Li, J., Szeles, A., Gizatullin, R. Z., Kashuba, V. I., Lushnikova, T., Protopopov, A. I., Kelve, M., Kiss, H., Kholodnyuk, I. D., Imreh, S., Klein, G. & Zabarovsky, E. R., 1 Jan 1997, In: Cytogenetic and Genome Research. 79, 3-4, p. 228-230 3 p.

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Differential elimination of 3p and retention of 3q segments in human/mouse microcell hybrids during tumor growth

Imreh, S., Kost-Alimova, M., Kholodnyuk, I., Yang, Y., Szeles, A., Kiss, H., Liu, Y., Foster, K., Zabarovsky, E., Stanbridge, E. & Klein, G., Nov 1997, In: Genes Chromosomes and Cancer. 20, 3, p. 224-233 10 p.

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Human/mouse microcell hybrid based elimination test reduces the putative tumor suppressor region at 3p21.3 to 1.6 cM

Szeles, A., Yang, Y., Sandlund, A. M., Kholodnyuk, I., Kiss, H., Kost-Alimova, M., Zabarovsky, E. R., Stanbridge, E., Klein, G. & Imreh, S., Dec 1997, In: Genes Chromosomes and Cancer. 20, 4, p. 329-336 8 p.

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

1996

Loss of heterozygosity on chromosome arm 3p in nasopharyngeal carcinoma

Hu, L. F., Eiriksdottir, G., Lebedeva, T., Kholodniouk, I., Alimov, A., Chen, F., Luo, Y., Zabarovsky, E. R., Ingvarsson, S., Klein, G. & Ernberg, I., Oct 1996, In: Genes Chromosomes and Cancer. 17, 2, p. 118-126 9 p.

Research output: Contribution to journal › Article › peer-review

58 Citations (Scopus)

NotI jumping and linking clones as a tool for genome mapping and analysis of chromosome rearrangements in different tumors

Zabarovsky, E. R., Kashuba, V. I., Gizatullin, R. Z., Winberg, G., Zabarovska, V. I., Erlandsson, R., Domninsky, D. A., Bannikov, V. M., Pokrovskaya, E. & Kholodnyuk, I., 1996, In: Cancer Detection and Prevention. 20, 1, p. 1-10 10 p.

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

1994

Construction of Representative NotI Linking Libraries Specific for the Total Human Genome and for Human Chromosome 3

Zabarovsky, E. R., Allikmets, R., Kholodnyuk, I., Zabarovska, V. I., Paulsson, N., Bannikov, V. M., Kashuba, V. I., Dean, M., Kisselev, L. L. & Klein, G., 15 Mar 1994, In: Genomics. 20, 2, p. 312-316 5 p.

Research output: Contribution to journal › Article › peer-review

38 Citations (Scopus)

Nonrandom loss of human chromosome 3 fragments from mouse‐human microcell hybrids following progressive growth in SCID mice

Imreh, S., Kholodnyuk, I., Allikmetts, R., Stanbridge, E. J., Zabarovsky, E. R. & Klein, G., Dec 1994, In: Genes, Chromosomes and Cancer. 11, 4, p. 237-245 9 p.

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Noti linking clones as a tool for joining physical and genetic maps of the human genome

Allikmets, R. L., Kashuba, V. I., Pettersson, B., Gizatullin, R., Lebedeva, T., Kholodnyuk, I. D., Bannikov, V. M., Petrov, N., Zakharyev, V. M., Winberg, G., Modi, W., Dean, M., Uhlén, M., Kisselev, L. L., Klein, G. & Zabarovsky, E. R., 15 Jan 1994, In: Genomics. 19, 2, p. 303-309 7 p.

Research output: Contribution to journal › Article › peer-review

49 Citations (Scopus)

Rapid Mapping of NotI Linking Clones with Differential Hybridization and Alu-PCR

Zabarovsky, E. R., Kashuba, V. I., Kholodnyuk, I. D., Zabarovska, V. I., Stanbridge, E. J. & Klein, G., Jun 1994, In: Genomics. 21, 3, p. 486-489 4 p.

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Irina Holodņuka

Research output

Search results