Activities per year
Project Details
Description
Immunoglobulin A nephropathy (IgAN) is an autoimmune disease and the most common form of primary glomerulonephritis. Patients present with heterogeneous clinicopathological manifestations and variable prognosis. The mechanisms of IgAN pathogenesis remain poorly defined but both B cells and microbiota are implicated. Our study will be the first to characterize the peripheral B cell subsets and function and explore possible interplay with intestinal microbiome diversity in IgAN patients. It is likely that intestinal dysbiosis in IgAN leads to aberrant B cell activation and differentiation towards antibody-producing plasma cells as opposed to regulatory B cells. This is in turn associated with a break in tolerance in IgAN pathogenesis. We will investigate peripheral B cell phenotype by flow cytometry and function in vitro, sequence the fecal microbiome, assess bacterial translocation markers and gut-derived uremic toxins in patients with histologically proven IgAN selected from renal biopsy registry at Pauls Stradins Clinical University Hospital compared to the healthy individuals. The findings of this study will contribute significantly to understanding of IgAN pathogenesis, and may enable patient subtyping for disease management and limit disease progression, and ultimately the discovery of non-invasive disease-specific biomarkers for earlier diagnosis and development of new therapies.
Status | Finished |
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Effective start/end date | 1/01/20 → 30/06/23 |
Links | https://www.rsu.lv/en/project/dissecting-interplay-between-intestinal-dysbiosis-and-b-cell-function-pathogenesis |
Total Funding
- Latvian Council of Science: €299,799.00
UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):
Keywords
- Immunoglobulin A nephropathy
- chronic kidney disease
- autoimmunity
- B cells; microbiome
Field of Science
- 3.2 Clinical medicine
Smart Specialization Area
- Biomedicine, medical technologies and biotechnology
Fingerprint
Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.
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Virtual Prague School on Flow Cytometry 2021
Šlisere, B. (Participant)
18 Oct 2021 → 21 Oct 2021Activity: Participating in or organising an event types › Participating in a conference, workshop, ...
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Serum complement C3 and C4 levels: prognostic factors in immunoglobulin A nephropathy
Popova, A. (Speaker)
24 Mar 2021Activity: Talk or presentation types › Poster presentation
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Dissecting the interplay between intestinal dysbiosis and B cell function in the pathogenesis of immunoglobulin A nephropathy
Popova, A. (Speaker)
24 Mar 2021Activity: Talk or presentation types › Oral presentation