High Hydrostatic Pressure: A Dual-Function Method for Processing and Sterilizing Drug-Loaded Hydrogels

The research project will focus on the high hydrostatic pressure sterilization HHP method, widely applied in the cosmetics and food industry. HHP benefits from a low-temperature load, applicability to liquid/gel-like and unstable structures. Although the HHP method has been known for more than a century, limited research has been done, and unreliable information exists about the application on drug-loaded hydrogel HG. The novelty of the topic is proved by the fact that there is not much data in the literature on the use of HHP in HG sterilization. The most recent literature highlights a possibility that the sterilization process can be accompanied by controlled alterations in the HGs swelling characteristics and drug release profile. Literature highlights the need for optimization in the HHP process to enhance the sterility, physical and drug release properties of HGs. Given the complexity of numerous parameters and variables at play, this project aims to employ an innovative Artificial Intelligence/Machine Learning AI/ML algorithm for precision process optimization. The project aims to design a dual-function processing method based on high hydrostatic pressure (HHP) for producing drug-loaded hydrogel with enhanced pharmaceutical properties.