Investigation of the effect of microcrystalline cellulose type and roll compaction force on the properties of granules and tablets containing a high dose of poorly compactible substance

Mohylyuk, Valentyn (Project leader)
Kukuls, Kirils (Leading expert)

Lead Researcher Group

Status	Finished
Effective start/end date	14/10/25 → 28/02/26
Links	https://www.linkedin.com/feed/update/urn:li:activity:7340082345590362112

Keywords

solid dosage forms
granulation
dry granulation
roll compaction
compaction
compaction simulation
tableting
mechanical properties
disintegration
microcrystalline cellulose
metformin
dissolution

Field of Science

2.5 Materials engineering
2.4 Chemical engineering
1.4 Chemical sciences
3.3 Health sciences

Smart Specialization Area

Smart materials, technology and engineering

Access Project

https://www.linkedin.com/feed/update/urn:li:activity:7340082345590362112

Effect of microcrystalline cellulose (MCC) type and roll compaction force on the mechanical properties of tablets containing a high dose of poorly compactible substance
Mohylyuk, V. (Corresponding Author), Kukuls, K., Frolova, A. J., Buczkowska, E. M. & Shmyrova, J., 24 Mar 2026. 1 p.
Research output: Contribution to conference › Poster › peer-review

Open Access
Fingerprints of Distinct Types of Microcrystalline Cellulose (MCC): Does the MCC Type Matter for Tableting?
Mohylyuk, V., Pelloux, A. & Kukuls, K., Sept 2024. 1 p.
Research output: Contribution to conference › Poster
The Effect of Microcrystalline Cellulose–CaHPO4 Mixtures in Different Volume Ratios on the Compaction and Structural–Mechanical Properties of Tablets
Mohylyuk, V. (Corresponding Author), Paulausks, A., Radzins, O. & Lauberte, L., 5 Mar 2024, In: Pharmaceutics. 16, 3, 362.
Research output: Contribution to journal › Article › peer-review

Open Access
File
7 Citations (Scopus)

9 Downloads (Pure)

1 Hosting a non-academic visitor
1 Poster presentation
1 Visiting an external non-academic institution

Asahi Kasei Europe GmbH
Mohylyuk, V. (Visiting researcher)
10 Jun 2025
Activity: Visiting an external institution types › Visiting an external non-academic institution
Mechanical properties of tablets: direct compression vs. twin-screw melt granulation with PEG 8000
Mohylyuk, V. (Speaker), Horvath, Z. M. (Co-author), Kukuls, K. (Co-author) & Paulausks, A. (Co-author)
21 May 2024 → 23 May 2024
Activity: Talk or presentation types › Poster presentation

File
Julia Shmyrova
Mohylyuk, V. (Host)
17 Nov 2023
Activity: Hosting a visitor types › Hosting a non-academic visitor

1 Active
3 Finished

Direct compression of highly used excipients in pharmaceutical tablet manufacturing: calcium phosphate dibasic anhydrous and microcrystalline cellulose
Kukuls, K. (Participant) & Mohylyuk, V. (Project leader)
1/08/23 → 31/07/27
Project: Projects outside RSU
Laboratory trial service
Mohylyuk, V. (Project leader) & Kukuls, K. (Leading expert)
13/05/25 → 12/06/25
Project: Contract research › R&D project
CONTRACT No 3-L-9/27/2024 On laboratory trial services
Mohylyuk, V. (Project leader) & Kukuls, K. (Expert)
26/06/24 → 23/08/24
Project: Contract research › R&D project

News » Effect of microcrystalline cellulose (MCC) type and roll compaction force on the mechanical properties of tablets containing a high dose of poorly compactible substance
Mohylyuk, V., Kukuls, K., Frolova, A. J., Buczkowska, E. M. & Shmyrova, J.
12/05/26
1 item of Media coverage
Press/Media