Activities per year
Project Details
Description
Second-level professional higher education study programme "Industrial pharmacy"
Layman's description
This research investigates isomalt as an alternative binding agent to polyvinylpyrrolidone in high-shear wet granulation processes. While isomalt has established applications in food production as a sweetener and bulking agent, its binding properties are of interest in pharmaceutical formulations development.
The experimental work comprised systematic evaluation of granulation processes and resulting product characteristics through controlled high-shear wet granulation experiments. Analysis focused on critical parameters including particle size distribution, flow properties, moisture content, tablet hardness, friability, and disintegration time.
The experimental work comprised systematic evaluation of granulation processes and resulting product characteristics through controlled high-shear wet granulation experiments. Analysis focused on critical parameters including particle size distribution, flow properties, moisture content, tablet hardness, friability, and disintegration time.
Key findings
Results demonstrated that the granulation process with isomalt solution was less sensitive to the change in isomalt concentration, suggesting a higher reproducibility of the granulation process with isomalt compared to the PVP. The isomalt functions as an effective binding agent, producing granules and tablets with distinct physical properties, notably faster disintegration times compared to polyvinylpyrrolidone. While meeting basic requirements, isomalt-containing formulations exhibited different mechanical strength characteristics, suggesting specific applications in formulations where rapid disintegration is advantageous.
Status | Finished |
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Effective start/end date | 1/03/24 → 7/01/25 |
UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):
Keywords
- pharmaceutical excipients
- isomalt
- polyvinylpyrrolidone
- wet granulation
- binders
- tablets
Field of Science
- 1.4 Chemical sciences
- 2.3 Mechanical engineering
- 3.3 Health sciences
Smart Specialization Area
- Knowledge-based bioeconomy
- Smart materials, technology and engineering
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Activities
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Isomalt as PVP-Binder Replacement in High-Shear Wet Granulation for Tablet Preparation
Pekša, M. M. (Speaker), Luhn, O. (Co-author) & Mohylyuk, V. (Co-author)
24 Mar 2025 → 25 Mar 2025Activity: Talk or presentation types › Poster presentation
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Effect of Magnesium Stearate Amount on the Tableting of Spray-dried Grades of Mannitol and Fluid-Bed Granulated Grade of Isomalt
Mohylyuk, V. (Speaker), Kukuls, K. (Co-author), Frolova, A. J. (Co-author), Horvath, Z. M. (Co-author) & Gniazdowska, E. M. (Co-author)
24 Mar 2025 → 25 Mar 2025Activity: Talk or presentation types › Poster presentation
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Oliver Luhn
Mohylyuk, V. (Host)
7 Aug 2024 → 9 Aug 2024Activity: Hosting a visitor types › Hosting a non-academic visitor