Isomalt as polyvinylpyrrolidone replacement in high-shear wet granulation and tablet preparation

Project Details

Description

Second-level professional higher education study programme "Industrial pharmacy"

Layman's description

This research investigates isomalt as an alternative binding agent to polyvinylpyrrolidone in high-shear wet granulation processes. While isomalt has established applications in food production as a sweetener and bulking agent, its binding properties are of interest in pharmaceutical formulations development.
The experimental work comprised systematic evaluation of granulation processes and resulting product characteristics through controlled high-shear wet granulation experiments. Analysis focused on critical parameters including particle size distribution, flow properties, moisture content, tablet hardness, friability, and disintegration time.

Key findings

Results demonstrated that the granulation process with isomalt solution was less sensitive to the change in isomalt concentration, suggesting a higher reproducibility of the granulation process with isomalt compared to the PVP. The isomalt functions as an effective binding agent, producing granules and tablets with distinct physical properties, notably faster disintegration times compared to polyvinylpyrrolidone. While meeting basic requirements, isomalt-containing formulations exhibited different mechanical strength characteristics, suggesting specific applications in formulations where rapid disintegration is advantageous.
StatusFinished
Effective start/end date1/03/247/01/25

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being
  • SDG 4 - Quality Education
  • SDG 9 - Industry, Innovation, and Infrastructure

Keywords

  • pharmaceutical excipients
  • isomalt
  • polyvinylpyrrolidone
  • wet granulation
  • binders
  • tablets

Field of Science

  • 1.4 Chemical sciences
  • 2.3 Mechanical engineering
  • 3.3 Health sciences

Smart Specialization Area

  • Knowledge-based bioeconomy
  • Smart materials, technology and engineering

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