Oral microbiome and inflammatory dynamics in Stage III periodontitis: comparative effects of mouthwash formulations containing Latvian-grown Coriandrum sativum essential oil versus standard chlorhexidine regimen.

The project investigates the impact of Latvian-grown Coriandrum sativum essential oil (CSEO) mouthwash on Stage III periodontitis, a severe form of periodontal disease linked to systemic health issues. Addressing the limitations of broad-spectrum antibacterials like chlorhexidine (CHX), it aims to study CSEO's ability to selectively target pathogenic oral bacteria, thereby reducing inflammation and improving oral health. The project encompasses in vitro studies to determine the optimal concentration of essential oil, followed by a randomized, placebo-controlled, double-blind clinical trial to compare its effectiveness with CHX in clinical settings. Key outcomes will include the modulation of oral microbiome, salivary inflammatory markers and potential improvement in treatment and healing outcomes after the mechanical treatment. We believe that the results of this project might provide us with new tools to navigate through the complexity of human microbial ecosystems - new tools for innovative, consciously crafted interventions into the microbial realm, stepping towards personalized oral care and addressing antimicrobial resistance, while also promoting ecological responsibility.