Personalised Risk Assessment in Febrile Illness to Optimise Real-life Management across the European Union

Project Details


The primary aim is the improvement of diagnostics and care of febrile patients, which are a significant burden and responsibility of a number of both primary, as well as tertiary health care facilities, with the aim to identify and apply promising new markers, both biological and clinical phenotypic – in viral and bacterial differential diagnostics.

The project also aims to differentiate between bacterial and viral infections by confirming the most accurate of them. A potential group of patients (primary, secondary and tertiary care) will be studied and a comprehensive fever management plan suitable for health care systems across the Europe will be developed.

During the study, access to febrile patients will take place at phenotypic, transcryptomic (Genome and Proteome) and bioinformatics level that will characterize multi-national cohort of patients at a large-scale. In addition, study data of past large-scale multi-national studies will be used.
Effective start/end date1/01/1631/12/21


  • European Commission: €17,997,665.50


  • Personalised medicine
  • biomarkers
  • antibiotic resistance
  • stainability of health systems
  • public health
  • febrile illness
  • bacterial infection
  • viral infection

Field of Science

  • 3.3 Health sciences

Smart Specialization Area

  • Biomedicine, medical technologies and biotechnology


Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.
  • Availability and use of rapid diagnostic tests for the management of acute childhood infections in Europe: A cross-sectional survey of paediatricians

    Dewez, J. E., Pembrey, L., Nijman, R. G., del Torso, S., Grossman, Z., Hadjipanayis, A., Van Esso, D., Lim, E., Emonts, M., Burns, J., Gras-LeGuen, C., Kohlfuerst, D., Dornbusch, H. J., Brengel-Pesce, K., Mallet, F., von Both, U., Tsolia, M., Eleftheriou, I., Zavadska, D., de Groot, R., & 34 othersvan der Flier, M., Moll, H., Hagedoorn, N., Borensztajn, D., Oostenbrink, R., Kuijpers, T., Pokorn, M., Vincek, K., Martinó n-Torres, F., Rivero, I., Agyeman, P., Carrol, E. D., Paulus, S., Cunnington, A., Herberg, J., Levin, M., Mujkić, A., Geitmann, K., Da Dalt, L., Valiulis, A., Lapatto, R., Syridou, G., Altorjai, P., Torpiano, P., Størdal, K., Illy, K., Mazur, A., Spreitzer, M. V., Rios, J., Wyder, C., Romankevych, I., Basmaci, R., Ibanez-Mico, S. & Yeung, S., Dec 2022, In: PloS one. 17, 12 , e0275336.

    Research output: Contribution to journalArticlepeer-review

    Open Access
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