Project Details
Description
The primary aim is the improvement of diagnostics and care of febrile patients, which are a significant burden and responsibility of a number of both primary, as well as tertiary health care facilities, with the aim to identify and apply promising new markers, both biological and clinical phenotypic – in viral and bacterial differential diagnostics.
The project also aims to differentiate between bacterial and viral infections by confirming the most accurate of them. A potential group of patients (primary, secondary and tertiary care) will be studied and a comprehensive fever management plan suitable for health care systems across the Europe will be developed.
During the study, access to febrile patients will take place at phenotypic, transcryptomic (Genome and Proteome) and bioinformatics level that will characterize multi-national cohort of patients at a large-scale. In addition, study data of past large-scale multi-national studies will be used.
The project also aims to differentiate between bacterial and viral infections by confirming the most accurate of them. A potential group of patients (primary, secondary and tertiary care) will be studied and a comprehensive fever management plan suitable for health care systems across the Europe will be developed.
During the study, access to febrile patients will take place at phenotypic, transcryptomic (Genome and Proteome) and bioinformatics level that will characterize multi-national cohort of patients at a large-scale. In addition, study data of past large-scale multi-national studies will be used.
| Acronym | PERFORM |
|---|---|
| Status | Finished |
| Effective start/end date | 1/01/16 → 31/12/21 |
| Links | https://www.rsu.lv/en/project/personalised-risk-assessment-febrile-illness-optimise-real-life-management-across-european |
Collaborative partners
- Rīga Stradiņš University
- London School of Hygiene and Tropical Medicine
- University of Liverpool
- Imperial College of Science Technology and Medicine (lead)
- University of Oxford
- Newcastle University
- National and Kapodistrian University of Athens
- The Galician Health Service
- Medical University of Graz
- University Medical Center Ljubljana
- Medical Research Council
- Micropathology Limited
- BioMerieux
- Ludwig Maximilian University of Munich
- University of Bern
- The Erasmus University Medical Centre
- Amsterdam UMC
- Radboud University Nijmegen
Total Funding
- European Commission: €17,997,665.50
Keywords
- Personalised medicine
- biomarkers
- antibiotic resistance
- stainability of health systems
- public health
- febrile illness
- bacterial infection
- viral infection
Field of Science
- 3.3 Health sciences
Smart Specialization Area
- Biomedicine, medical technologies and biotechnology
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Research output
- 1 Article
-
Availability and use of rapid diagnostic tests for the management of acute childhood infections in Europe: A cross-sectional survey of paediatricians
Dewez, J. E., Pembrey, L., Nijman, R. G., del Torso, S., Grossman, Z., Hadjipanayis, A., Van Esso, D., Lim, E., Emonts, M., Burns, J., Gras-LeGuen, C., Kohlfuerst, D., Dornbusch, H. J., Brengel-Pesce, K., Mallet, F., von Both, U., Tsolia, M., Eleftheriou, I., Zavadska, D. & de Groot, R. & 34 others, , Dec 2022, In: PloS one. 17, 12 , e0275336.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (Scopus)24 Downloads (Pure)