Prostate cancer-derived extracellular vesicles as liquid biopsies and therapeutic targets

The main aim of this project is to develop novel tools for the isolation of prostate cancer (PC)-derived EVs from human biofluids and to gain a deeper understanding into the RNA content and biodistribution of various PC-derived EV subsets and to assess the therapeutic potential of their depletion from the circulation.

This project is expected to generate antibodies against PC-specific EV surface markers and to characterise RNA content in PC-derived EV subpopulations, as well as assess the therapeutic potential of PC-derived EV depletion from the circulation. This will generate a solid basis for the development of clinically applicable diagnostic products for the detection of clinically significant PC and pave the way for the development of novel therapeutic strategies.