Systemic and muscle tissue-specific metabolic adaptations to EXercise and POlyphenol supplementation in aging: modulatory effects of SEstrins (EXPOSE)

Sestrins (SESNs), a family of evolutionarily conserved proteins, emerge as key physiological regulators in cellular adaptation to diverse stress stimuli. Scientific evidence highlights SESNs as potential biomarkers and significant regulators of muscle function in aging, therefore the aim of this study is: a) to provide reference of plasma SESN values in healthy young and older adults at baseline, during exercise, and in recovery in relation to their physical performance capacity; b) to investigate the systemic and muscle tissue-specific SESN-mediated metabolic adaptations to a polyphenol supplementation (PS), resistance training (RT) and their combined effect by performing comprehensive analysis of multiple factors involved.