Targeting autoimmune mechanisms for prevention of gastric neuroendocrine tumours

The prevalence of different autoimmune disorders (AID) constantly increases. Autoimmune atrophic gastritis (AAG) is an organ-specific disease that is primarily asymptomatic in the early stages, and often the cause of these AAG cases is unclear. This project aims to investigate determinants of the AAG development and transformation to G-NET in a complex manner. We will specifically explore the impact of local and systemic immune regulators, microbiome composition and functionality, alterations in gastric tissue transcriptome and immune profiles upon specific exogenous and endogenous factor interaction, as well as relation to other autoimmune disease development and micronutrient deficiencies. The specific objectives: (1) To investigate AAG incidence in patients with other autoimmune disease backgrounds by evaluation of immunogenic properties and microbial component contribution to early AAG development; (2) To determine gastric microbiota diversity and functionality alterations in two-year follow-up in AAG and G-NET patients; (3) To profile immune-landscape by characterization of neopterin levels, cytokine profiles and evaluation of T helper immunoreactivity; (4) To evaluate zinc, selenium, iodine, magnesium, manganese and D and E vitamin levels in AAG patients to estimate whether AAG contributes to the decrease of specific micronutrient blood levels or AAG could be linked with other AID via impaired micronutrient regulation.