Tumour cell response to acute aerobic exercise in breast cancer survivors: modulatory effects of exercise type and intensity

Cancer has emerged as a prominent cause of mortality in the 21st century, with breast cancer (BC) being the most diagnosed malignancy. Multidisciplinary cancer management has improved survival chances, but side effects and long-term consequences of treatments have significant implications for cancer survivors' health-related quality of life. Exercise is increasingly considered and used in cancer treatment and follow-up. However, studies demonstrating the biological mechanisms underlying the anticarcinogenic effects (ACE) of exercise are insufficient to justify the most appropriate physical activity for different clinical scenarios. Achieving scientific excellence in understanding the ACE of exercise in cancer management is critical to optimize treatment and enhance patients' quality of life.
Aim: to identify the most effective and feasible modality of acute aerobic exercise in BC survivors based on exercise-conditioned serum (ECS) induced ACE on BC cell behavior in vitro.
The TCReX project is registered on the clinicaltrials.gov and has been assigned the identification number: NCT07439458.