β- and γ-melanocortins inhibit lipopolysaccharide induced nitric oxide production in mice brain

Ruta Muceniece, Liga Zvejniece, Olga Kirjanova, Edgars Liepinsh, Liga Krigere, Larisa Baumane, Ivars Kalvinsh, Jarl E.S. Wikberg, Maija Dambrova

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

The pro-opiomelanocortin-derived peptide α-melanocyte stimulating hormone (α-MSH) mediates many diverse physiological actions, including anti-inflammatory and immunomodulatory effects. However, little is known about the physiological roles of the other melanocortins, β- and γ-MSH. Here, we investigated the effects of melanocortin peptides in an in vivo neuroinflammation model. Six hours following intracisternal (i.c.) administration of 10 μg lipopolysaccharide (LPS) to mice a five-fold increase in the nitric oxide (NO) level was seen in the animals' brains, when detected by electron paramagnetic resonance (EPR). All tested melanocortins, α-, β-, γ1- and γ2-MSH (0.001-10 nmol/mouse i.c.), dose dependently reduced the LPS induced increases in brain NO, with an order of effectiveness: β-MSH≥γ1-MSH=γ2-MSH>α-MSH. Our results suggest specialized functions of β- and γ-MSH melanocortins in inflammatory signal modulation in the brain.

Original languageEnglish
Pages (from-to)7-13
Number of pages7
JournalBrain Research
Volume995
Issue number1
DOIs
Publication statusPublished - 2 Jan 2004
Externally publishedYes

Keywords

  • Brain inflammation
  • Electron paramagnetic resonance
  • Lipopolysaccharide
  • Melanocortin
  • Nitric oxide

Field of Science

  • 3.1 Basic medicine
  • 1.6 Biological sciences

Publication Type

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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