A case of stage IV chromophobe renal cell carcinoma treated with the oncolytic ECHO-7 virus, rigvir®

Zaurbek Ismailov, Agnija Rasa (Coresponding Author), Katrīna Bandere, Linda Brokāne, Andra Tilgase, Evija Olmane, Jurijs Nazarovs, Pēteris Alberts

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Objective: Unusual or unexpected effect of treatment Background: Renal cell carcinoma is the most commonly diagnosed primary malignant tumor of the kidney in adults, and includes the variant of chromophobe renal cell carcinoma. Despite new targeted therapies that improve progression- free survival (PFS) and overall survival (OS) for early-stage renal cell carcinoma, the 5-year survival for patients with stage IV renal cell carcinoma remains below 10%, and the 50% OS is less than one year. Metastatic renal cell carcinoma can be resistant to cytotoxic chemotherapy. This report is of a case of stage IV chromophobe renal cell carcinoma that responded well to treatment with the oncolytic ECHO-7 virus, Rigvir®. Case Report: In December 2015, a 59-year-old man presented with a right-sided chromophobe renal cell carcinoma stage IV (pT 1 N 0 M 1 ) with adrenal gland metastasis. He underwent right nephro-adrenalectomy followed by treatments with Rigvir® (≥106 TCID 50 /ml) by intramuscular (i.m.) injection on three consecutive days. Treatment with Rigvir® continued once per week for three months, and from March 2016, once per month, with continued treatment until computed tomography (CT) scans confirmed that the tumor metastases had stabilized. Conclusions: This case report has demonstrated that the oncolytic.

Original languageEnglish
Pages (from-to)48-52
Number of pages5
JournalAmerican Journal of Case Reports
Publication statusPublished - 2019
Externally publishedYes


  • Carcinoma
  • Oncolytic virotherapy
  • Oncolytic viruses
  • Renal cell

Field of Science*

  • 3.2 Clinical medicine

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database


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