TY - JOUR
T1 - A New Surgical Technique to Deliver Riboflavin Beneath Corneal Epithelium
T2 - The Corneal Cross-Linking Epi-Pocket
AU - Borroni, Davide
AU - Bonzano, Chiara
AU - Hristova, Rozaliya
AU - Sánchez González, José María
AU - Pennisi, Flavia
AU - Rocha-Bogas, Aurelio
AU - Rocha de Lossada, Carlos
N1 - Publisher Copyright:
Copyright © 2021 Asia-Pacific Academy of Ophthalmology. Published by Wolters Kluwer Health, Inc. on behalf of the Asia-Pacific Academy of Ophthalmology.
PY - 2021/9/14
Y1 - 2021/9/14
N2 - PURPOSE: To describe a new technique to deliver riboflavin into the corneal stroma during Corneal Cross-Linking (CXL) without the removal of corneal epithelium. METHODS: Keratoconus patients underwent CXL for progressive keratoconus. Riboflavin was delivered by manually creating an epithelial pocket (CXL Epi-Pocket). Verbal rating scale was recorded postoperatively. Best-corrected visual acuity, keratometric indices, corneal thickness and corneal densitometry were recorded at baseline and at 12-month follow-up. RESULTS: Eighteen eyes of 18 patients were included in the study. At a 12-month follow-up, best-corrected visual acuity, K1, K2 and densitometry values were stable. Maximum keratometry (Kmax) reduced from 55.31 ± 6.21 (SD) to 52.34d ± 4.12d (SD) (P value = 0.032). the thinnest point went from 441 ± 21.18 (SD) to 425.4 ± 19.02 (SD) um (P value = 0.041). The verbal rating scale at 1, 2 and 3 days postoperatively were 1.76 ± 0.19 (SD), 1.02 ± 0.51 (SD) and 0.28 ± 0.14 (SD). CONCLUSIONS: CXL Epi-Pocket is able to deliver riboflavin to halt the progression of keratoconus at a 12-month follow-up.
AB - PURPOSE: To describe a new technique to deliver riboflavin into the corneal stroma during Corneal Cross-Linking (CXL) without the removal of corneal epithelium. METHODS: Keratoconus patients underwent CXL for progressive keratoconus. Riboflavin was delivered by manually creating an epithelial pocket (CXL Epi-Pocket). Verbal rating scale was recorded postoperatively. Best-corrected visual acuity, keratometric indices, corneal thickness and corneal densitometry were recorded at baseline and at 12-month follow-up. RESULTS: Eighteen eyes of 18 patients were included in the study. At a 12-month follow-up, best-corrected visual acuity, K1, K2 and densitometry values were stable. Maximum keratometry (Kmax) reduced from 55.31 ± 6.21 (SD) to 52.34d ± 4.12d (SD) (P value = 0.032). the thinnest point went from 441 ± 21.18 (SD) to 425.4 ± 19.02 (SD) um (P value = 0.041). The verbal rating scale at 1, 2 and 3 days postoperatively were 1.76 ± 0.19 (SD), 1.02 ± 0.51 (SD) and 0.28 ± 0.14 (SD). CONCLUSIONS: CXL Epi-Pocket is able to deliver riboflavin to halt the progression of keratoconus at a 12-month follow-up.
KW - corneal epithelium
KW - corneal cross-linking epi-pocket
KW - keratoconus
KW - riboflavin
UR - http://www.scopus.com/inward/record.url?scp=85117739820&partnerID=8YFLogxK
U2 - 10.1097/APO.0000000000000420
DO - 10.1097/APO.0000000000000420
M3 - Article
C2 - 34524144
AN - SCOPUS:85117739820
SN - 2162-0989
VL - 10
SP - 495
EP - 498
JO - Asia-Pacific journal of ophthalmology (Philadelphia, Pa.)
JF - Asia-Pacific journal of ophthalmology (Philadelphia, Pa.)
IS - 5
ER -