A novel polymer for potential use in a trileaflet heart valve

Siobhain L. Gallocher, Andres F. Aguirre, Vladimir Kasyanov, Leonard Pinchuk, Richard T. Schoephoerster

Research output: Contribution to journalArticlepeer-review

58 Citations (Scopus)

Abstract

A novel polyolefin, poly(styrene-b-isobutylene-b-styrene) (Quatromer™), is being proposed as a viable polymer for use in trileaflet heart valves because of its oxidative stability. The current study was designed to assess the polymer's hemocompatibility and mechanical durability. Mechanical characterization included static tensile tests and dynamic tension-tension and bending fatigue tests, where the properties of isotropic and composite (polypropylene (PP) embedded) Quatromer specimens were compared with those of a polyurethane (PUR) approved for cardiovascular applications. It was found that by embedding PP fibers into the Quatromer matrix, the tensile and fatigue properties of the polymer could be improved, making them comparable, if not better than the PUR. The thrombotic potential of Quatromer was compared with the PUR, glutaraldehyde-fixed porcine valve material, and a positive and negative control by measuring platelet deposition with radiolabeled platelets in a parallel plate flow configuration. The porcine valve material was found to have significantly higher platelet deposition under all flow regimes, while no significant difference existed between Quatromer and PUR. In conclusion, Quatromer is shown to have suitable hemocompatibility and mechanical durability for use in polymer trileaflet heart valves, and fiber reinforcement can effectively be used to tailor the mechanical properties.

Original languageEnglish
Pages (from-to)325-334
Number of pages10
JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
Volume79
Issue number2
DOIs
Publication statusPublished - Nov 2006

Keywords*

  • Fatigue
  • Heart valve
  • Mechanical properties
  • Platelet deposition
  • Poly(styrene-b-isobutylene-b-styrene)

Field of Science*

  • 2.5 Materials engineering
  • 2.6 Medical engineering

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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