A novel polymer for potential use in a trileaflet heart valve

Siobhain L. Gallocher, Andres F. Aguirre, Vladimir Kasyanov, Leonard Pinchuk, Richard T. Schoephoerster

    Research output: Contribution to journalArticlepeer-review

    61 Citations (Scopus)

    Abstract

    A novel polyolefin, poly(styrene-b-isobutylene-b-styrene) (Quatromer™), is being proposed as a viable polymer for use in trileaflet heart valves because of its oxidative stability. The current study was designed to assess the polymer's hemocompatibility and mechanical durability. Mechanical characterization included static tensile tests and dynamic tension-tension and bending fatigue tests, where the properties of isotropic and composite (polypropylene (PP) embedded) Quatromer specimens were compared with those of a polyurethane (PUR) approved for cardiovascular applications. It was found that by embedding PP fibers into the Quatromer matrix, the tensile and fatigue properties of the polymer could be improved, making them comparable, if not better than the PUR. The thrombotic potential of Quatromer was compared with the PUR, glutaraldehyde-fixed porcine valve material, and a positive and negative control by measuring platelet deposition with radiolabeled platelets in a parallel plate flow configuration. The porcine valve material was found to have significantly higher platelet deposition under all flow regimes, while no significant difference existed between Quatromer and PUR. In conclusion, Quatromer is shown to have suitable hemocompatibility and mechanical durability for use in polymer trileaflet heart valves, and fiber reinforcement can effectively be used to tailor the mechanical properties.

    Original languageEnglish
    Pages (from-to)325-334
    Number of pages10
    JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
    Volume79
    Issue number2
    DOIs
    Publication statusPublished - Nov 2006

    Keywords*

    • Fatigue
    • Heart valve
    • Mechanical properties
    • Platelet deposition
    • Poly(styrene-b-isobutylene-b-styrene)

    Field of Science*

    • 2.5 Materials engineering
    • 2.6 Medical engineering

    Publication Type*

    • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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