A pilot study on markers of genetic predisposition in tuberculous pneumonia patients in Latgale

Ksenija Kramiča; Jeļena Eglite; Aleksandrs Koļesovs; Tatjana Kramiča; Gaļina Titoviča; Diana Džeriņa; Glafira Nikolajeva; Ludmila Viksna; Oksana Koļesova

doi:10.2478/prolas-2019-0030

A pilot study on markers of genetic predisposition in tuberculous pneumonia patients in Latgale

Ksenija Kramiča, Jeļena Eglite, Aleksandrs Koļesovs, Tatjana Kramiča, Gaļina Titoviča, Diana Džeriņa, Glafira Nikolajeva, Ludmila Viksna, Oksana Koļesova

Department of Infectology

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Abstract

Tuberculosis (TB) is still one of the top ten leading causes of death in the world. Compared to other Baltic and Eastern European countries, TB incidence (24.8 new cases per 100 000 people in 2017) in Latvia is relatively high. One of the regions with the highest TB incidence is Latgale (31.1 cases per 100 000 people). The aim of this pilot study was to identify markers of genetic predisposition to TB in Latgale. The study included 26 patients (16 males and 10 females) aged between 18 and 85 with bilateral TB pneumonia and without HIV infection. HLA typing was performed in HLA-DRB1, -DQA1, and -DQB1 loci by a polymerase chain reaction with low resolution sequence-specific primers. HLA-DRB1∗07 and HLA-DRB1∗11 alleles were identified as risk alleles for TB. HLA-DRB1∗15 allele was a protective allele. Due to the limitations of this exploratory study, a broader study needs to be conducted to revealing specific risk and protective HLA Class II alleles for TB in the subpopulation of Latgale.

Original language	English
Pages (from-to)	189-191
Number of pages	3
Journal	Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences
Volume	73
Issue number	2
DOIs	https://doi.org/10.2478/prolas-2019-0030
Publication status	Published - 1 May 2019

Keywords*

HLA Class II
Latgale
tuberculosis

Field of Science*

1.6 Biological sciences
3.1 Basic medicine
3.2 Clinical medicine

Publication Type*

1.1. Scientific article indexed in Web of Science and/or Scopus database

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2478/prolas-2019-0030

A PILOT STUDY ON MARKERS OF GENETICLicence: CC BY-NC-ND

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Kramiča, K., Eglite, J., Koļesovs, A., Kramiča, T., Titoviča, G., Džeriņa, D., Nikolajeva, G., Viksna, L., & Koļesova, O. (2019). A pilot study on markers of genetic predisposition in tuberculous pneumonia patients in Latgale. Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences, 73(2), 189-191. https://doi.org/10.2478/prolas-2019-0030

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title = "A pilot study on markers of genetic predisposition in tuberculous pneumonia patients in Latgale",

abstract = "Tuberculosis (TB) is still one of the top ten leading causes of death in the world. Compared to other Baltic and Eastern European countries, TB incidence (24.8 new cases per 100 000 people in 2017) in Latvia is relatively high. One of the regions with the highest TB incidence is Latgale (31.1 cases per 100 000 people). The aim of this pilot study was to identify markers of genetic predisposition to TB in Latgale. The study included 26 patients (16 males and 10 females) aged between 18 and 85 with bilateral TB pneumonia and without HIV infection. HLA typing was performed in HLA-DRB1, -DQA1, and -DQB1 loci by a polymerase chain reaction with low resolution sequence-specific primers. HLA-DRB1∗07 and HLA-DRB1∗11 alleles were identified as risk alleles for TB. HLA-DRB1∗15 allele was a protective allele. Due to the limitations of this exploratory study, a broader study needs to be conducted to revealing specific risk and protective HLA Class II alleles for TB in the subpopulation of Latgale.",

keywords = "HLA Class II, Latgale, tuberculosis",

author = "Ksenija Krami{\v c}a and Jeļena Eglite and Aleksandrs Koļesovs and Tatjana Krami{\v c}a and Gaļina Titovi{\v c}a and Diana D{\v z}eriņa and Glafira Nikolajeva and Ludmila Viksna and Oksana Koļesova",

year = "2019",

month = may,

day = "1",

doi = "10.2478/prolas-2019-0030",

language = "English",

volume = "73",

pages = "189--191",

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Kramiča, K, Eglite, J, Koļesovs, A, Kramiča, T, Titoviča, G, Džeriņa, D, Nikolajeva, G, Viksna, L & Koļesova, O 2019, 'A pilot study on markers of genetic predisposition in tuberculous pneumonia patients in Latgale', Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences, vol. 73, no. 2, pp. 189-191. https://doi.org/10.2478/prolas-2019-0030

A pilot study on markers of genetic predisposition in tuberculous pneumonia patients in Latgale. / Kramiča, Ksenija; Eglite, Jeļena; Koļesovs, Aleksandrs et al.
In: Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences, Vol. 73, No. 2, 01.05.2019, p. 189-191.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - A pilot study on markers of genetic predisposition in tuberculous pneumonia patients in Latgale

AU - Kramiča, Ksenija

AU - Eglite, Jeļena

AU - Koļesovs, Aleksandrs

AU - Kramiča, Tatjana

AU - Titoviča, Gaļina

AU - Džeriņa, Diana

AU - Nikolajeva, Glafira

AU - Viksna, Ludmila

AU - Koļesova, Oksana

PY - 2019/5/1

Y1 - 2019/5/1

N2 - Tuberculosis (TB) is still one of the top ten leading causes of death in the world. Compared to other Baltic and Eastern European countries, TB incidence (24.8 new cases per 100 000 people in 2017) in Latvia is relatively high. One of the regions with the highest TB incidence is Latgale (31.1 cases per 100 000 people). The aim of this pilot study was to identify markers of genetic predisposition to TB in Latgale. The study included 26 patients (16 males and 10 females) aged between 18 and 85 with bilateral TB pneumonia and without HIV infection. HLA typing was performed in HLA-DRB1, -DQA1, and -DQB1 loci by a polymerase chain reaction with low resolution sequence-specific primers. HLA-DRB1∗07 and HLA-DRB1∗11 alleles were identified as risk alleles for TB. HLA-DRB1∗15 allele was a protective allele. Due to the limitations of this exploratory study, a broader study needs to be conducted to revealing specific risk and protective HLA Class II alleles for TB in the subpopulation of Latgale.

AB - Tuberculosis (TB) is still one of the top ten leading causes of death in the world. Compared to other Baltic and Eastern European countries, TB incidence (24.8 new cases per 100 000 people in 2017) in Latvia is relatively high. One of the regions with the highest TB incidence is Latgale (31.1 cases per 100 000 people). The aim of this pilot study was to identify markers of genetic predisposition to TB in Latgale. The study included 26 patients (16 males and 10 females) aged between 18 and 85 with bilateral TB pneumonia and without HIV infection. HLA typing was performed in HLA-DRB1, -DQA1, and -DQB1 loci by a polymerase chain reaction with low resolution sequence-specific primers. HLA-DRB1∗07 and HLA-DRB1∗11 alleles were identified as risk alleles for TB. HLA-DRB1∗15 allele was a protective allele. Due to the limitations of this exploratory study, a broader study needs to be conducted to revealing specific risk and protective HLA Class II alleles for TB in the subpopulation of Latgale.

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KW - tuberculosis

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DO - 10.2478/prolas-2019-0030

M3 - Article

AN - SCOPUS:85065639882

SN - 1407-009X

VL - 73

SP - 189

EP - 191

JO - Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences

JF - Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences

IS - 2

ER -

A pilot study on markers of genetic predisposition in tuberculous pneumonia patients in Latgale

Abstract

Keywords*

Field of Science*

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UN SDGs

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