A worldwide perspective of sepsis epidemiology and survival according to age: Observational data from the ICON audit

Katarzyna Kotfis; Xavier Wittebole; Ulrich Jaschinski; Jordi  Solé-Violán; Rahul   Kashyap; Marc    Leone; Jean-Louis Vincent; ICON Investigators; Indulis Vanags; Viesturs Liguts

doi:doi: 10.1016/j.jcrc.2019.02.015.

A worldwide perspective of sepsis epidemiology and survival according to age: Observational data from the ICON audit

Katarzyna Kotfis, Xavier Wittebole, Ulrich Jaschinski, Jordi Solé-Violán, Rahul Kashyap, Marc Leone, Jean-Louis Vincent (Corresponding Author), ICON Investigators, Indulis Vanags (Member of the Working Group), Viesturs Liguts (Member of the Working Group)

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

Purpose: To investigate age-related differences in outcomes of critically ill patients with sepsis around the world.

Methods: We performed a secondary analysis of data from the prospective ICON audit, in which all adult (>16 years) patients admitted to participating ICUs between May 8 and 18, 2012, were included, except admissions for routine postoperative observation. For this sub-analysis, the 10,012 patients with completed age data were included. They were divided into five age groups - ≤50, 51-60, 61-70, 71-80, >80 years. Sepsis was defined as infection plus at least one organ failure.

Results: A total of 2963 patients had sepsis, with similar proportions across the age groups (≤50 = 25.2%; 51-60 = 30.3%; 61-70 = 32.8%; 71-80 = 30.7%; >80 = 30.9%). Hospital mortality increased with age and in patients >80 years was almost twice that of patients ≤50 years (49.3% vs 25.2%, p < .05). The maximum rate of increase in mortality was about 0.75% per year, occurring between the ages of 71 and 77 years. In multilevel analysis, age > 70 years was independently associated with increased risk of dying.

Conclusions: The odds for death in ICU patients with sepsis increased with age with the maximal rate of increase occurring between the ages of 71 and 77 years.

Original language	English
Article number	51
Pages (from-to)	122-132
Number of pages	11
Journal	Journal of Critical Care
Volume	51
DOIs	https://doi.org/doi: 10.1016/j.jcrc.2019.02.015.
Publication status	Published - Jun 2019
Externally published	Yes

Keywords*

ICU; Mortality; Outcome.

Field of Science*

3.3 Health sciences
3.2 Clinical medicine

Publication Type*

1.1. Scientific article indexed in Web of Science and/or Scopus database

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doi: 10.1016/j.jcrc.2019.02.015.

Cite this

Kotfis, K., Wittebole, X., Jaschinski, U., Solé-Violán, J., Kashyap, R., Leone, M., Vincent, J.-L., ICON Investigators, Vanags, I., & Liguts, V. (2019). A worldwide perspective of sepsis epidemiology and survival according to age: Observational data from the ICON audit. Journal of Critical Care, 51, 122-132. Article 51. https://doi.org/doi: 10.1016/j.jcrc.2019.02.015.

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title = "A worldwide perspective of sepsis epidemiology and survival according to age: Observational data from the ICON audit",

abstract = "Purpose: To investigate age-related differences in outcomes of critically ill patients with sepsis around the world.Methods: We performed a secondary analysis of data from the prospective ICON audit, in which all adult (>16 years) patients admitted to participating ICUs between May 8 and 18, 2012, were included, except admissions for routine postoperative observation. For this sub-analysis, the 10,012 patients with completed age data were included. They were divided into five age groups - ≤50, 51-60, 61-70, 71-80, >80 years. Sepsis was defined as infection plus at least one organ failure.Results: A total of 2963 patients had sepsis, with similar proportions across the age groups (≤50 = 25.2%; 51-60 = 30.3%; 61-70 = 32.8%; 71-80 = 30.7%; >80 = 30.9%). Hospital mortality increased with age and in patients >80 years was almost twice that of patients ≤50 years (49.3% vs 25.2%, p < .05). The maximum rate of increase in mortality was about 0.75% per year, occurring between the ages of 71 and 77 years. In multilevel analysis, age > 70 years was independently associated with increased risk of dying.Conclusions: The odds for death in ICU patients with sepsis increased with age with the maximal rate of increase occurring between the ages of 71 and 77 years.",

keywords = "ICU; Mortality; Outcome.",

author = "Katarzyna Kotfis and Xavier Wittebole and Ulrich Jaschinski and Jordi Sol{\'e}-Viol{\'a}n and Rahul Kashyap and Marc Leone and Rahul Nanchal and Fontes, {Luis E.} and Yasser Sakr and Jean-Louis Vincent and {ICON Investigators} and Indulis Vanags and Viesturs Liguts",

note = "PMID: 30802758",

year = "2019",

month = jun,

doi = "doi: 10.1016/j.jcrc.2019.02.015.",

language = "English",

volume = "51",

pages = "122--132",

journal = "Journal of Critical Care",

issn = "0883-9441",

publisher = "Elsevier BV",

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T1 - A worldwide perspective of sepsis epidemiology and survival according to age

T2 - Observational data from the ICON audit

AU - Kotfis, Katarzyna

AU - Wittebole, Xavier

AU - Jaschinski, Ulrich

AU - Solé-Violán, Jordi

AU - Kashyap, Rahul

AU - Leone, Marc

AU - Nanchal , Rahul

AU - Fontes, Luis E.

AU - Sakr, Yasser

AU - Vincent, Jean-Louis

AU - ICON Investigators

A2 - Vanags, Indulis

A2 - Liguts, Viesturs

N1 - PMID: 30802758

PY - 2019/6

Y1 - 2019/6

N2 - Purpose: To investigate age-related differences in outcomes of critically ill patients with sepsis around the world.Methods: We performed a secondary analysis of data from the prospective ICON audit, in which all adult (>16 years) patients admitted to participating ICUs between May 8 and 18, 2012, were included, except admissions for routine postoperative observation. For this sub-analysis, the 10,012 patients with completed age data were included. They were divided into five age groups - ≤50, 51-60, 61-70, 71-80, >80 years. Sepsis was defined as infection plus at least one organ failure.Results: A total of 2963 patients had sepsis, with similar proportions across the age groups (≤50 = 25.2%; 51-60 = 30.3%; 61-70 = 32.8%; 71-80 = 30.7%; >80 = 30.9%). Hospital mortality increased with age and in patients >80 years was almost twice that of patients ≤50 years (49.3% vs 25.2%, p < .05). The maximum rate of increase in mortality was about 0.75% per year, occurring between the ages of 71 and 77 years. In multilevel analysis, age > 70 years was independently associated with increased risk of dying.Conclusions: The odds for death in ICU patients with sepsis increased with age with the maximal rate of increase occurring between the ages of 71 and 77 years.

AB - Purpose: To investigate age-related differences in outcomes of critically ill patients with sepsis around the world.Methods: We performed a secondary analysis of data from the prospective ICON audit, in which all adult (>16 years) patients admitted to participating ICUs between May 8 and 18, 2012, were included, except admissions for routine postoperative observation. For this sub-analysis, the 10,012 patients with completed age data were included. They were divided into five age groups - ≤50, 51-60, 61-70, 71-80, >80 years. Sepsis was defined as infection plus at least one organ failure.Results: A total of 2963 patients had sepsis, with similar proportions across the age groups (≤50 = 25.2%; 51-60 = 30.3%; 61-70 = 32.8%; 71-80 = 30.7%; >80 = 30.9%). Hospital mortality increased with age and in patients >80 years was almost twice that of patients ≤50 years (49.3% vs 25.2%, p < .05). The maximum rate of increase in mortality was about 0.75% per year, occurring between the ages of 71 and 77 years. In multilevel analysis, age > 70 years was independently associated with increased risk of dying.Conclusions: The odds for death in ICU patients with sepsis increased with age with the maximal rate of increase occurring between the ages of 71 and 77 years.

KW - ICU; Mortality; Outcome.

U2 - doi: 10.1016/j.jcrc.2019.02.015.

DO - doi: 10.1016/j.jcrc.2019.02.015.

M3 - Article

SN - 0883-9441

VL - 51

SP - 122

EP - 132

JO - Journal of Critical Care

JF - Journal of Critical Care

M1 - 51

ER -

A worldwide perspective of sepsis epidemiology and survival according to age: Observational data from the ICON audit

Abstract

Keywords*

Field of Science*

Publication Type*

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