Inflammation process has significant role in biocompatibility modelling process. Bone loss induced by inflammation is one of the complications after biomaterial implantation into the hard tissue. There is no complete data about time dependent expression of cytokines and defensins into the bone tissue after implantation of biomaterials. The aim of this experiment was to research the changes on distribution and appearance of immune defense profile proteins - Interleukins-1, -8, -10 and human β defensin2 in the lower jaw of rabbits after implantation of pure hydroxyapatite and tricalcium phosphate and mixed tricalcium phosphate/hydroxyapatite produced under different temperatures. Our results revealed that biomaterials - pure and mixed HAP and TCP produced under different temperatures don't make significant difference to IL-1, IL-8, IL-10 and HBD2 production. Bone developing zones and low expression of anti-inflammatory cytokines in experimental tissue with both type of HAP/TCP and with TCP material burned under 10000 C possibly indicates better biocompatibility for this material than others used in our study.