Activity of host defense proteins in rabbit bone after pure hydroxyapatite and tricalcium phosphate and mixed tricalcium phosphate/hydroxyapatite implantation

J. Vamze, M. Pilmane, A. Skagers

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Inflammation process has significant role in biocompatibility modelling process. Bone loss induced by inflammation is one of the complications after biomaterial implantation into the hard tissue. There is no complete data about time dependent expression of cytokines and defensins into the bone tissue after implantation of biomaterials. The aim of this experiment was to research the changes on distribution and appearance of immune defense profile proteins - Interleukins-1, -8, -10 and human β defensin2 in the lower jaw of rabbits after implantation of pure hydroxyapatite and tricalcium phosphate and mixed tricalcium phosphate/hydroxyapatite produced under different temperatures. Our results revealed that biomaterials - pure and mixed HAP and TCP produced under different temperatures don't make significant difference to IL-1, IL-8, IL-10 and HBD2 production. Bone developing zones and low expression of anti-inflammatory cytokines in experimental tissue with both type of HAP/TCP and with TCP material burned under 10000 C possibly indicates better biocompatibility for this material than others used in our study.

Original languageEnglish
Title of host publicationInternational Symposium on Biomedical Engineering and Medical Physics, ISBEMP 2012
Pages110-112
Number of pages3
DOIs
Publication statusPublished - 2013
EventInternational Symposium on Biomedical Engineering and Medical Physics - Riga, Latvia
Duration: 10 Oct 201212 Oct 2012

Publication series

NameIFMBE Proceedings
Volume38 IFMBE
ISSN (Print)1680-0737

Conference

ConferenceInternational Symposium on Biomedical Engineering and Medical Physics
Abbreviated title ISBEMP 2012
CountryLatvia
CityRiga
Period10/10/1212/10/12

Keywords

  • biomaterials
  • human β - defensin
  • Interleukins
  • rabbit

Field of Science

  • 2.6 Medical engineering
  • 3.1 Basic medicine
  • 3.2 Clinical medicine

Publication Type

  • 3.2. Articles or chapters in other proceedings other than those included in 3.1., with an ISBN or ISSN code

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