Acute anti-hyperglycaemic effects of an unripe apple preparation containing phlorizin in healthy volunteers: A preliminary study

Elina Makarova, Pawel Górnaś, Ilze Konrade, Dace Tirzite, Helena Cirule, Anita Gulbe, Iveta Pugajeva, Dalija Seglina, Maija Dambrova

Research output: Contribution to journalArticlepeer-review

56 Citations (Scopus)

Abstract

BACKGROUND: The health-promoting properties of apples are directly related to the biologically active compounds that they contain, such as polyphenols. The objective of this study was to prepare a low-sugar, fibre- and phlorizin-enriched powder from unripe apples and to gain insight regarding its anti-hyperglycaemic activity in healthy volunteers. RESULTS: The unripe apples (Malus domestica Borkh.) were collected 30 days after the full bloom day; blanched and pressed to obtain apple pomace which was then processed with a food cutter, oven-dried and milled to prepare apple powder. The concentrations of total sugars, water-soluble pectin and phlorizin in the apple preparation were 153.44±2.46, 27.73±0.51 and 12.61±0.15 g kg-1, respectively. Acute ingestion of the apple preparation improved glucose metabolism in the oral glucose tolerance test (OGTT) in six healthy volunteers by reducing the postprandial glucose response at 15 to 30 min by approximately two-fold (P < 0.05) and by increasing urinary glucose excretion during the 2- to 4-h interval of the OGTT by five-fold (P < 0.05). CONCLUSION: The results obtained indicate that the dried and powdered pomace of unripe apples can be used as a health-promoting natural product for the reduction of postprandial glycaemia and to improve the health of patients with diabetes.

Original languageEnglish
Pages (from-to)560-568
Number of pages9
JournalJournal of the Science of Food and Agriculture
Volume95
Issue number3
DOIs
Publication statusPublished - 4 Jul 2014

Keywords*

  • Fibre
  • Glucose excretion
  • Glucose tolerance test
  • Phlorizin
  • Polyphenols
  • Unripe apples

Field of Science*

  • 3.1 Basic medicine
  • 3.3 Health sciences

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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