Aerobic vaginitis in pregnancy

G. G.G. Donders, G. Bellen, D. Rezeberga

Research output: Contribution to journalReview articlepeer-review

131 Citations (Scopus)


Aerobic vaginitis (AV) is an alteration in vaginal bacterial flora that differs from bacterial vaginosis (BV). AV is characterised by an abnormal vaginal microflora accompanied by an increased localised inflammatory reaction and immune response, as opposed to the suppressed immune response that is characteristic of BV. Given the increased local production of interleukin (IL)-1, IL-6 and IL-8 associated with AV during pregnancy, not surprisingly AV is associated with an increased risk of preterm delivery, chorioamnionitis and funisitis of the fetus. There is no consensus on the optimal treatment for AV in pregnant or non-pregnant women, but a broader spectrum drug such as clindamycin is preferred above metronidazole to prevent infection-related preterm birth. The exact role of AV in pregnancy, the potential benefit of screening, and the use of newer local antibiotics, disinfectants, probiotics and immune modulators need further study.

Original languageEnglish
Pages (from-to)1163-1170
Number of pages8
JournalBJOG: An International Journal of Obstetrics and Gynaecology
Issue number10
Publication statusPublished - Sept 2011


  • Abnormal vaginal flora
  • aerobic vaginitis
  • bacterial vaginosis
  • chorioamnionitis
  • intrauterine infection
  • intrauterine inflammatory syndrome
  • preterm birth
  • vaginitis

Field of Science*

  • 3.2 Clinical medicine

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database


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