Alcoholism and cellular vulnerability in different brain regions

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Alcohol-induced damage causes dysfunction of selected brain regions. Multidisciplinary studies have provided an extensive description of changes observed in neurons and glia following alcohol consumption. In this study the authors have elucidated preferential cellular vulnerability in three different brain regions. Autopsy material of the prefrontal cortex, striatum, and substantia nigra obtained from the brain tissue of alcoholic subjects was used in this study. We found that dendritic tree and astroglial damage is irreversible, while neuronal somata and most axons do not display irreversible changes.

Original languageEnglish
Pages (from-to)40-47
Number of pages8
JournalUltrastructural Pathology
Volume36
Issue number1
DOIs
Publication statusPublished - Feb 2012

Keywords

  • Alcohol
  • electron microscopy
  • myelin sheath
  • prefrontal cortex
  • striatum
  • substantia nigra
  • synapses

Field of Science

  • 1.6 Biological sciences
  • 3.1 Basic medicine

Publication Type

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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