Abstract
Alcohol-induced damage causes dysfunction of selected brain regions. Multidisciplinary studies have provided an extensive description of changes observed in neurons and glia following alcohol consumption. In this study the authors have elucidated preferential cellular vulnerability in three different brain regions. Autopsy material of the prefrontal cortex, striatum, and substantia nigra obtained from the brain tissue of alcoholic subjects was used in this study. We found that dendritic tree and astroglial damage is irreversible, while neuronal somata and most axons do not display irreversible changes.
| Original language | English |
|---|---|
| Pages (from-to) | 40-47 |
| Number of pages | 8 |
| Journal | Ultrastructural Pathology |
| Volume | 36 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Feb 2012 |
Keywords*
- Alcohol
- electron microscopy
- myelin sheath
- prefrontal cortex
- striatum
- substantia nigra
- synapses
Field of Science*
- 1.6 Biological sciences
- 3.1 Basic medicine
Publication Type*
- 1.1. Scientific article indexed in Web of Science and/or Scopus database
