TY - JOUR
T1 - Alkylresorcinol metabolites in urine and plasma as potential biomarkers of rye and wheat fiber consumption in prostate cancer patients and controls
AU - Meija, Laila
AU - Krams, Indrikis
AU - Cauce, Vinita
AU - Samaletdin, Adile
AU - Söderholm, Paivi
AU - Meija, Raimonds
AU - Larmane, Liga
AU - Lejnieks, Aivars
AU - Lietuvietis, Vilnis
AU - Adlercreutz, Herman
N1 - Publisher Copyright:
© 2015 Coypright © 2015 Taylor & Francis Group, LLC.
Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 2015/2/17
Y1 - 2015/2/17
N2 - Alkylresorcinols (ARs) are phytochemicals mainly associated with rye/wheat bran. Plasma ARs and their plasma and urine metabolites are considered as biomarkers for whole-grain rye/wheat intake. However ARs metabolite day and night variations have not been studied in prostate cancer patients yet. We investigated ARs metabolites 3, 5-dihydroxy-benzoic acid (DHBA), and 3-(3, 5-dihydroxyphenyl)-1-propanoic acid (DHPPA) in urine and plasma in prostate cancer patients and in control group. DHPPA in 12-h overnight urine correlated with the intake of rye bread and bread fiber across short time periods (3 days). Plasma DHPPA concentration was significantly greater in the prostate cancer group than in the control group. DHPPA and DHBA excretion was significantly higher in the overnight urine than in day urine in the prostate cancer group but not in the control group. DHPPA concentration in plasma in the prostate cancer group did not depend on the intake of rye bread in the previous day, suggesting an impaired metabolism of ARs metabolites in the prostate cancer group. The results of this study suggest DHPPA in 12-h overnight urine as a biomarker to estimate the intake of rye bread and bread fiber.
AB - Alkylresorcinols (ARs) are phytochemicals mainly associated with rye/wheat bran. Plasma ARs and their plasma and urine metabolites are considered as biomarkers for whole-grain rye/wheat intake. However ARs metabolite day and night variations have not been studied in prostate cancer patients yet. We investigated ARs metabolites 3, 5-dihydroxy-benzoic acid (DHBA), and 3-(3, 5-dihydroxyphenyl)-1-propanoic acid (DHPPA) in urine and plasma in prostate cancer patients and in control group. DHPPA in 12-h overnight urine correlated with the intake of rye bread and bread fiber across short time periods (3 days). Plasma DHPPA concentration was significantly greater in the prostate cancer group than in the control group. DHPPA and DHBA excretion was significantly higher in the overnight urine than in day urine in the prostate cancer group but not in the control group. DHPPA concentration in plasma in the prostate cancer group did not depend on the intake of rye bread in the previous day, suggesting an impaired metabolism of ARs metabolites in the prostate cancer group. The results of this study suggest DHPPA in 12-h overnight urine as a biomarker to estimate the intake of rye bread and bread fiber.
UR - http://www.scopus.com/inward/record.url?scp=84924507872&partnerID=8YFLogxK
U2 - 10.1080/01635581.2015.989371
DO - 10.1080/01635581.2015.989371
M3 - Article
C2 - 25608053
AN - SCOPUS:84924507872
SN - 0163-5581
VL - 67
SP - 258
EP - 265
JO - Nutrition and Cancer
JF - Nutrition and Cancer
IS - 2
ER -
