TY - JOUR
T1 - An inherited variant in the gene coding for vitamin D-binding protein and survival from cutaneous melanoma
T2 - A BioGenoMEL study
AU - Davies, John R.
AU - Field, Sinead
AU - Randerson-Moor, Juliette
AU - Harland, Mark
AU - Kumar, Rajiv
AU - Anic, Gabriella M.
AU - Nagore, Eduardo
AU - Hansson, Johan
AU - Höiom, Veronica
AU - Jönsson, Göran
AU - Gruis, Nelleke A.
AU - Park, Jong Y.
AU - Guan, Jian
AU - Sivaramakrishna Rachakonda, P.
AU - Wendt, Judith
AU - Pjanova, Dace
AU - Puig, Susana
AU - Schadendorf, Dirk
AU - Okamoto, Ichiro
AU - Olsson, Håkan
AU - Affleck, Paul
AU - García-Casado, Zaida
AU - Puig-Butille, Joan Anton
AU - Stratigos, Alexander J.
AU - Kodela, Elizabeth
AU - Donina, Simona
AU - Sucker, Antje
AU - Hosen, Ismail
AU - Egan, Kathleen M.
AU - Barrett, Jennifer H.
AU - van Doorn, Remco
AU - Bishop, D. Timothy
AU - Newton-Bishop, Julia
PY - 2014/3
Y1 - 2014/3
N2 - An association between low serum vitamin D levels and poorer melanoma survival has been reported. We have studied inheritance of a polymorphism of the GC gene, rs2282679, coding for the vitamin D-binding protein, which is associated with lower serum levels of vitamin D, in a meta-analysis of 3137 melanoma patients. The aim was to investigate evidence for a causal relationship between vitamin D and outcome (Mendelian randomization). The variant was not associated with reduced overall survival (OS) in the UK cohort, per-allele hazard ratio (HR) for death 1.23 (95% confidence interval (CI) 0.93, 1.64). In the smaller cohorts, HR in OS analysis was 1.07 (95% CI 0.88, 1.3) and for all cohorts combined, HR for OS was 1.09 (95% CI 0.93, 1.29). There was evidence of increased melanoma-specific deaths in the seven cohorts for which these data were available. The lack of unequivocal findings despite the large sample size illustrates the difficulties of implementing Mendelian randomization.
AB - An association between low serum vitamin D levels and poorer melanoma survival has been reported. We have studied inheritance of a polymorphism of the GC gene, rs2282679, coding for the vitamin D-binding protein, which is associated with lower serum levels of vitamin D, in a meta-analysis of 3137 melanoma patients. The aim was to investigate evidence for a causal relationship between vitamin D and outcome (Mendelian randomization). The variant was not associated with reduced overall survival (OS) in the UK cohort, per-allele hazard ratio (HR) for death 1.23 (95% confidence interval (CI) 0.93, 1.64). In the smaller cohorts, HR in OS analysis was 1.07 (95% CI 0.88, 1.3) and for all cohorts combined, HR for OS was 1.09 (95% CI 0.93, 1.29). There was evidence of increased melanoma-specific deaths in the seven cohorts for which these data were available. The lack of unequivocal findings despite the large sample size illustrates the difficulties of implementing Mendelian randomization.
KW - GC
KW - Melanoma
KW - Mendelian randomization
KW - Survival analysis
KW - Vitamin D
UR - http://www.scopus.com/inward/record.url?scp=84894029248&partnerID=8YFLogxK
U2 - 10.1111/pcmr.12193
DO - 10.1111/pcmr.12193
M3 - Article
C2 - 24219834
AN - SCOPUS:84894029248
SN - 1755-1471
VL - 27
SP - 234
EP - 243
JO - Pigment Cell and Melanoma Research
JF - Pigment Cell and Melanoma Research
IS - 2
ER -