Anti-herpesviral effects of a novel broad range anti-microbial quaternary ammonium silane, K21

Nitish Gulve; Kirk Kimmerling; Allen D Johnston; Gerhard R Krueger; Dharam V Ablashi; Bhupesh K Prusty

doi:10.1016/j.antiviral.2016.05.004

Anti-herpesviral effects of a novel broad range anti-microbial quaternary ammonium silane, K21

Nitish Gulve, Kirk Kimmerling, Allen D Johnston, Gerhard R Krueger, Dharam V Ablashi, Bhupesh K Prusty (Corresponding Author)

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

We have created a novel quaternary ammonium silane, K21 through sol-gel chemistry, using an ethoxylated version of an organosilane quaternary ammonium compound and TetraEthyl Ortho Silicate (TEOS) as precursors. Previous studies using the precursor molecule quaternary ammonium compounds (QACs) and a methacryloxy version of K21, primarily designed for use in dental healthcare, have shown inhibited growth properties against several types of gram-positive and gram-negative bacteria including Escherichia coli, Streptococcus mutans, Actinomyces naeslundii and Candida albicans etc. Here we tested the effect of K21 on HSV-1, HHV-6A and HHV-7 in in vitro cell culture infection models. Our results show growth inhibitory effect of K21 on HSV-1, HHV-6A and HHV-7 infection.

Original language	English
Pages (from-to)	166-73
Number of pages	8
Journal	Antiviral Research
Volume	131
DOIs	https://doi.org/10.1016/j.antiviral.2016.05.004
Publication status	Published - Jul 2016
Externally published	Yes

Keywords*

Antiviral Agents/chemistry
Herpesvirus 1, Human/drug effects
Herpesvirus 6, Human/drug effects
Herpesvirus 7, Human/drug effects
Quaternary Ammonium Compounds/chemistry
Silanes/chemistry

Field of Science*

3.1 Basic medicine
1.6 Biological sciences
3.3 Health sciences

Publication Type*

1.1. Scientific article indexed in Web of Science and/or Scopus database

Access to Document

10.1016/j.antiviral.2016.05.004

Cite this

@article{1d42e60e70874497922a928be9264b06,

title = "Anti-herpesviral effects of a novel broad range anti-microbial quaternary ammonium silane, K21",

abstract = "We have created a novel quaternary ammonium silane, K21 through sol-gel chemistry, using an ethoxylated version of an organosilane quaternary ammonium compound and TetraEthyl Ortho Silicate (TEOS) as precursors. Previous studies using the precursor molecule quaternary ammonium compounds (QACs) and a methacryloxy version of K21, primarily designed for use in dental healthcare, have shown inhibited growth properties against several types of gram-positive and gram-negative bacteria including Escherichia coli, Streptococcus mutans, Actinomyces naeslundii and Candida albicans etc. Here we tested the effect of K21 on HSV-1, HHV-6A and HHV-7 in in vitro cell culture infection models. Our results show growth inhibitory effect of K21 on HSV-1, HHV-6A and HHV-7 infection.",

keywords = "Antiviral Agents/chemistry, Herpesvirus 1, Human/drug effects, Herpesvirus 6, Human/drug effects, Herpesvirus 7, Human/drug effects, Quaternary Ammonium Compounds/chemistry, Silanes/chemistry",

author = "Nitish Gulve and Kirk Kimmerling and Johnston, {Allen D} and Krueger, {Gerhard R} and Ablashi, {Dharam V} and Prusty, {Bhupesh K}",

year = "2016",

month = jul,

doi = "10.1016/j.antiviral.2016.05.004",

language = "English",

volume = "131",

pages = "166--73",

journal = "Antiviral Research",

issn = "0166-3542",

publisher = "Elsevier",

}

TY - JOUR

T1 - Anti-herpesviral effects of a novel broad range anti-microbial quaternary ammonium silane, K21

AU - Gulve, Nitish

AU - Kimmerling, Kirk

AU - Johnston, Allen D

AU - Krueger, Gerhard R

AU - Ablashi, Dharam V

AU - Prusty, Bhupesh K

PY - 2016/7

Y1 - 2016/7

N2 - We have created a novel quaternary ammonium silane, K21 through sol-gel chemistry, using an ethoxylated version of an organosilane quaternary ammonium compound and TetraEthyl Ortho Silicate (TEOS) as precursors. Previous studies using the precursor molecule quaternary ammonium compounds (QACs) and a methacryloxy version of K21, primarily designed for use in dental healthcare, have shown inhibited growth properties against several types of gram-positive and gram-negative bacteria including Escherichia coli, Streptococcus mutans, Actinomyces naeslundii and Candida albicans etc. Here we tested the effect of K21 on HSV-1, HHV-6A and HHV-7 in in vitro cell culture infection models. Our results show growth inhibitory effect of K21 on HSV-1, HHV-6A and HHV-7 infection.

AB - We have created a novel quaternary ammonium silane, K21 through sol-gel chemistry, using an ethoxylated version of an organosilane quaternary ammonium compound and TetraEthyl Ortho Silicate (TEOS) as precursors. Previous studies using the precursor molecule quaternary ammonium compounds (QACs) and a methacryloxy version of K21, primarily designed for use in dental healthcare, have shown inhibited growth properties against several types of gram-positive and gram-negative bacteria including Escherichia coli, Streptococcus mutans, Actinomyces naeslundii and Candida albicans etc. Here we tested the effect of K21 on HSV-1, HHV-6A and HHV-7 in in vitro cell culture infection models. Our results show growth inhibitory effect of K21 on HSV-1, HHV-6A and HHV-7 infection.

KW - Antiviral Agents/chemistry

KW - Herpesvirus 1, Human/drug effects

KW - Herpesvirus 6, Human/drug effects

KW - Herpesvirus 7, Human/drug effects

KW - Quaternary Ammonium Compounds/chemistry

KW - Silanes/chemistry

UR - https://www-scopus-com.db.rsu.lv/record/display.uri?eid=2-s2.0-84969673994&origin=resultslist&sort=plf-f&src=s&sid=39ab08caa56344855a936564d3c75435&sot=b&sdt=b&s=TITLE%28Anti-herpesviral+effects+of+a+novel+broad+range+anti-microbial+quaternary+ammonium+silane%2C+K21%29&sl=101&sessionSearchId=39ab08caa56344855a936564d3c75435&relpos=0

U2 - 10.1016/j.antiviral.2016.05.004

DO - 10.1016/j.antiviral.2016.05.004

M3 - Article

C2 - 27181377

SN - 0166-3542

VL - 131

SP - 166

EP - 173

JO - Antiviral Research

JF - Antiviral Research

ER -

Anti-herpesviral effects of a novel broad range anti-microbial quaternary ammonium silane, K21

Abstract

Keywords*

Field of Science*

Publication Type*

Access to Document

Other files and links

Fingerprint

Cite this