Antioxidant defense and trace element imbalance in patients with postradiation syndrome: First report on phase I studies

Ausma O. Kumerova, Anna G. Lece, Andrejs P. Skesters, Grigorijs A. Orlikov, Juris V. Seleznev, K. D. Rainsford

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)

Abstract

More than 6000 residents of Latvia were involved in recovery work in Chernobyl. They were healthy men exposed to substantial ionizing radiation (0.01-0.5 Gy). Now, these recovery workers suffer from 'postradiation syndrome': Dizziness and poor memory, headache, local pains, and so forth. The biochemical mechanism of 'postradiation syndrome' has not been completely established. In this Phase I study, we have investigated how exposure to radiation impacts antioxidative defense and trace element concentrations in the blood of recovery workers. Thirty-five patients with postradiation syndrome (men, age range 33-50 yr) and 15 healthy men similar in age as control subjects were studied for the effects on plasma chemiluminescence, the activity of antioxidant enzymes, and the concentration of ceruloplasmin and concentrations of selenium (Se), zinc (Zn), and copper (Cu) in blood. The results revealed that plasma chemiluminescence was significantly increased (3.5-fold to 5.5-fold), the activity of catalase in erythrocytes was significantly elevated, and the activity of glutathione peroxidase in plasma was significantly reduced in examined patients. Concentrations of Zn and Cu were significantly higher and the concentration of Se was lower in these patients. We conclude that the patients exposed to ionizing radiation have diminished blood antioxidant defense associated with pronounced Se deficiency and imbalance of Zn and Cu.

Original languageEnglish
Pages (from-to)1-12
Number of pages12
JournalBiological Trace Element Research
Volume77
Issue number1
DOIs
Publication statusPublished - 2000
EventSFRR (Europe) Summer Meeting - DRESDEN, GERMANY, DRESDEN, Germany
Duration: 2 Jul 19996 Jul 1999

Keywords

  • Antioxidant defense
  • Catalase
  • Glutathione peroxidase
  • Postradiation syndrome
  • Trace elements

Field of Science

  • 3.1 Basic medicine
  • 3.2 Clinical medicine
  • 1.4 Chemical sciences
  • 1.6 Biological sciences

Publication Type

  • 3.1. Articles or chapters in proceedings/scientific books indexed in Web of Science and/or Scopus database

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