Antioxidant therapy and its stability on Chernobyl clean-up workers

Andrejs Skesters, Tija Zvagule, Alise Silova, Liga Larmane, Nina Rusakova, Natalja Kurjane, Elena Kirilova, Inta Kalnina, Georgii Kirilov, Natalija Gabruseva

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


This paper describes the effects of prolonged antioxidant therapy, its stability and association with spectral parameters of the fluorescent probe ABM in blood plasma and indices of albumin auto-fluorescence in Chernobyl clean-up workers from Latvia. Patients were divided into two groups. Group 1 received placebos of identical appearance to antioxidants. Group 2 received antioxidants (vitamin E + selenium + ibuprofen). Individuals were tested three times: before supplementation of antioxidants, after therapy and one year after supplementation interruption. Applied therapy improves oxidant/antioxidant status of individuals. Interruption of therapy after one year leads to significant decrease of cellular immunity. In the group receiving antioxidants it is not so expressed compared with data from the placebos group. Changes in blood plasma and its structural and functional properties detected by ABM strongly correlated with the oxidant/antioxidant (immune) status of individuals. This behaviour of ABM could be useful in reflecting alterations of cellular immunity. Questions related to more detailed and prolonged antioxidant therapy need closer investigation.

Original languageEnglish
Pages (from-to)409-421
Number of pages13
JournalInternational Journal of Low Radiation
Issue number5
Publication statusPublished - Nov 2010


  • Antioxidant therapy
  • Fluorescent probe
  • Human serum albumin
  • Ionising radiation

Field of Science*

  • 3.2 Clinical medicine

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database


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