Abstract
Background: Chronic venous insufficiency (CVI) may lead to leg ulceration (CVI stage C6) (Nicolaides A.N. et al., 2000). Some authors published that genetic risk factors are observed more frequently in patients with CVI stage C6. Also, an increased level of anticardiolipin antibodies (ACA) is observed in patients with CVI stage C6. CVI stage C6 more frequently develops in CVI stage C3 patients with positive antiphospholipid antibodies (APA) when compared to CVI stage C3 patients without APA.
Objective: To identify the association of single nucleotide polymorphisms (SNPs) of genes F5 (rs6025), F2 (rs1799963), SELE (rs5361), SERPINC1 (rs2227589), FGG (rs20066865), CYP4V2 (rs13146272), F11 (rs2289252), GP6 (rs1613662) and APA antibodies with CVI stage in the population of Latvia.
Methods: The study group consisted of 188 CVI patients. APA was detected in 89 CVI patients. The diagnostics of CVI was based on clinical and duplex ultrasound data (Philips Sparq, 2012). APA was detected using ELISA assay (according to the manufacturer’s protocol (Demeditec Diagnostics GmbH, Germany)). Statistical analysis was performed using Plink 1.06. Software and Fisher exact tests.
Results: Polymorphism of gene F11 (rs2289252) showed an association with CVI stage C6 (OR=1.81 (p=0.024). A statistically significant elevation of APA was observed in patients with CVI stage C6 when compared to patients with CVI stage C3 (p=0.05).
Conclusions: The polymorphism of gene F11 (rs2289252) and positive APA showed an association with CVI stage C6.
Objective: To identify the association of single nucleotide polymorphisms (SNPs) of genes F5 (rs6025), F2 (rs1799963), SELE (rs5361), SERPINC1 (rs2227589), FGG (rs20066865), CYP4V2 (rs13146272), F11 (rs2289252), GP6 (rs1613662) and APA antibodies with CVI stage in the population of Latvia.
Methods: The study group consisted of 188 CVI patients. APA was detected in 89 CVI patients. The diagnostics of CVI was based on clinical and duplex ultrasound data (Philips Sparq, 2012). APA was detected using ELISA assay (according to the manufacturer’s protocol (Demeditec Diagnostics GmbH, Germany)). Statistical analysis was performed using Plink 1.06. Software and Fisher exact tests.
Results: Polymorphism of gene F11 (rs2289252) showed an association with CVI stage C6 (OR=1.81 (p=0.024). A statistically significant elevation of APA was observed in patients with CVI stage C6 when compared to patients with CVI stage C3 (p=0.05).
Conclusions: The polymorphism of gene F11 (rs2289252) and positive APA showed an association with CVI stage C6.
| Original language | English |
|---|---|
| Pages (from-to) | 108-113 |
| Journal | International Journal of Clinical Rheumatology |
| Volume | 13 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2018 |
Keywords*
- single nucleotide polymorphisms
- trophic ulcers
- chronic venous insufficiency
- venous ulcer
- antiphospholipid antibodies
- anticardiolipin
- antibodies
- antiphospholipid
- syndrome
Field of Science*
- 3.2 Clinical medicine
Publication Type*
- 1.4. Reviewed scientific article published in Latvia or abroad in a scientific journal with an editorial board (including university editions)