Assessment of Factors Determining Efficacy of Cardiac Resynchronisation Therapy for Patients with Heart Failure in the Population of Latvia: summary

Research output: Types of ThesisDoctoral Thesis

Abstract

The Doctoral Thesis has been elaborated at the Latvian Centre of Cardiology, Pauls Stradiņš University Hospital, Rīga. Defence: at the public session of the Doctoral Council of Medicine on 27 January 2020 at 15.00 in Hippocrates Lecture Theatre, 16 Dzirciema Street, Rīga Stradiņš University.Introduction. Heart failure (HF) is one of the main causes of hospitalisation, disabilities and death worldwide and in Latvia as well. Pharmacological therapy often has proven to be ineffective since it fails to prevent uncoordinated ventricular contraction. Application of cardiac resynchronisation therapy (CRT) helps restore proper coordination between both ventricles, thus improving the HF prognosis. Nevertheless, it remains unclear what initial factors may affect the CRT efficiency. Aim. The aim of the study is to analyse progression of treatment and the factors affecting the efficiency in HF patients with moderate and severe clinical course with implanted cardiac resynchronisation devices. Methods. The prospective single-centre study analysed patients with HF who had undergone scheduled implantation of CRT. Efficiency of CRT was detected by echocardiography, studying the improvement in ejection fraction (EF) of the left ventricular after 12 and 24 months, respectively. ΔEF improvement ≥ 10% – CRT responders and ΔEF improvement 50 ms, SBP above 130 mm Hg.The doctoral thesis was carried out under financial support of the European Social Fund project “Support for doctoral study programmes and the acquisition of a scientific degree at Rīga Stradiņš University”
Original languageEnglish
Supervisors/Advisors
  • Kalējs, Oskars, First/Primary/Lead supervisor
  • Lejnieks, Aivars, Second/Co-supervisor
  • Ivanovs, Andrejs, Consultant/Advisor
  • Spalva, Kristīne, Consultant/Advisor, External person
Place of PublicationRīga
Publisher
DOIs
Publication statusPublished - 2019

Keywords

  • Cardiology
  • Doctoral Thesis

Field of Science

  • 3.2 Clinical medicine

Publication Type

  • 4. Doctoral Thesis

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