Assessment of some oxidative stress parameters in patients with bronchial asthma after selenium supplementation

Julia G. Voicehovska; A. Skesters; G. A. Orlikov; A. A. Silova; N. J. Rusakova; L. T. Larmane; J. G. Karpov; A. D. Ivanov; E. Maulinsh

doi:10.1134/S1990750808020108

Assessment of some oxidative stress parameters in patients with bronchial asthma after selenium supplementation

Julia G. Voicehovska, A. Skesters, G. A. Orlikov, A. A. Silova, N. J. Rusakova, L. T. Larmane, J. G. Karpov, A. D. Ivanov, E. Maulinsh

Department of Internal Diseases

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

The goal of this study was to investigate the effect of selenium deficit replenishment in patients with bronchial asthma (BA) on manifestations of oxidative stress and conditions of the antioxidant system (AOS). The need of correction of selenium deficit in BA-patients is determined by increased requirements in antioxidants due to chronic inflammatory process responsible for pathogenesis of BA. Latvia as well as Eastern Finland, Byelorussia, some regions of Ukraine, North-Western Russia, and New Zealand belong to the endemic areas with marked selenium deficit in soils and foodstuff. Twenty patients (7 men and 13 women) with selenium deficit and verified diagnosis of BA have been examined. In addition to basic therapy all patients received organic selenium as SelenoPRECISE (PharmaNord) 200 üg daily for 16 weeks. This caused statistically significant increase of plasma selenium from 50.94 ± 7.58 to 63.59 ± 10.87 μg/l (p < 0.001), the increase of selenium-dependent glutathione peroxidase (from 38.64 ± 10.72 U/g Hb to 58.57 ± 14.64 U/g Hb, p = 0.01). Treatment of patients with selenium also normalized the parameters characterizing oxidative stress (chemiluminescence), significantly exceeded normal values before this treatment. The use of selenium in addition to basic therapy allows to abolish or reduce oxidative stress by correcting the antioxidant system.

Original language	English
Pages (from-to)	189-193
Number of pages	5
Journal	Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry
Volume	2
Issue number	2
DOIs	https://doi.org/10.1134/S1990750808020108
Publication status	Published - Jun 2008

Keywords*

Bronchial asthma
Inflammation
Oxidative stress
Selenium

Field of Science*

3.1 Basic medicine

Publication Type*

1.1. Scientific article indexed in Web of Science and/or Scopus database

Access to Document

10.1134/S1990750808020108

Cite this

Voicehovska, J. G., Skesters, A., Orlikov, G. A., Silova, A. A., Rusakova, N. J., Larmane, L. T., Karpov, J. G., Ivanov, A. D., & Maulinsh, E. (2008). Assessment of some oxidative stress parameters in patients with bronchial asthma after selenium supplementation. Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry, 2(2), 189-193. https://doi.org/10.1134/S1990750808020108

@article{cabac248b287486ca71b12f0f214629d,

title = "Assessment of some oxidative stress parameters in patients with bronchial asthma after selenium supplementation",

abstract = "The goal of this study was to investigate the effect of selenium deficit replenishment in patients with bronchial asthma (BA) on manifestations of oxidative stress and conditions of the antioxidant system (AOS). The need of correction of selenium deficit in BA-patients is determined by increased requirements in antioxidants due to chronic inflammatory process responsible for pathogenesis of BA. Latvia as well as Eastern Finland, Byelorussia, some regions of Ukraine, North-Western Russia, and New Zealand belong to the endemic areas with marked selenium deficit in soils and foodstuff. Twenty patients (7 men and 13 women) with selenium deficit and verified diagnosis of BA have been examined. In addition to basic therapy all patients received organic selenium as SelenoPRECISE (PharmaNord) 200 {\"u}g daily for 16 weeks. This caused statistically significant increase of plasma selenium from 50.94 ± 7.58 to 63.59 ± 10.87 μg/l (p < 0.001), the increase of selenium-dependent glutathione peroxidase (from 38.64 ± 10.72 U/g Hb to 58.57 ± 14.64 U/g Hb, p = 0.01). Treatment of patients with selenium also normalized the parameters characterizing oxidative stress (chemiluminescence), significantly exceeded normal values before this treatment. The use of selenium in addition to basic therapy allows to abolish or reduce oxidative stress by correcting the antioxidant system.",

keywords = "Bronchial asthma, Inflammation, Oxidative stress, Selenium",

author = "Voicehovska, {Julia G.} and A. Skesters and Orlikov, {G. A.} and Silova, {A. A.} and Rusakova, {N. J.} and Larmane, {L. T.} and Karpov, {J. G.} and Ivanov, {A. D.} and E. Maulinsh",

note = "Funding Information: These studies were carried out whithin the grant no. 01.0730 “Reactive Oxygen Species in Experimental Model and Clinics” (P. Stradina University) and the grant Nr2004/0005/VPD1/ESF/P1AA/04/NP/3.2.3.1/0004/0066 “Employment of Selenium in Addition to Basic Therapy during Treatment of Patients with Bronchial Asthma” (European Foundation for the Development of Science in EU countries). SelenoPRECISE was obtained from PharmaNord ApS (Vojens, Denmark) within support of this project.",

year = "2008",

month = jun,

doi = "10.1134/S1990750808020108",

language = "English",

volume = "2",

pages = "189--193",

journal = "Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry",

issn = "1990-7508",

publisher = "Pleiades Publishing",

number = "2",

}

Voicehovska, JG , Skesters, A, Orlikov, GA, Silova, AA, Rusakova, NJ, Larmane, LT, Karpov, JG, Ivanov, AD & Maulinsh, E 2008, 'Assessment of some oxidative stress parameters in patients with bronchial asthma after selenium supplementation', Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry, vol. 2, no. 2, pp. 189-193. https://doi.org/10.1134/S1990750808020108

TY - JOUR

T1 - Assessment of some oxidative stress parameters in patients with bronchial asthma after selenium supplementation

AU - Voicehovska, Julia G.

AU - Skesters, A.

AU - Orlikov, G. A.

AU - Silova, A. A.

AU - Rusakova, N. J.

AU - Larmane, L. T.

AU - Karpov, J. G.

AU - Ivanov, A. D.

AU - Maulinsh, E.

N1 - Funding Information: These studies were carried out whithin the grant no. 01.0730 “Reactive Oxygen Species in Experimental Model and Clinics” (P. Stradina University) and the grant Nr2004/0005/VPD1/ESF/P1AA/04/NP/3.2.3.1/0004/0066 “Employment of Selenium in Addition to Basic Therapy during Treatment of Patients with Bronchial Asthma” (European Foundation for the Development of Science in EU countries). SelenoPRECISE was obtained from PharmaNord ApS (Vojens, Denmark) within support of this project.

PY - 2008/6

Y1 - 2008/6

N2 - The goal of this study was to investigate the effect of selenium deficit replenishment in patients with bronchial asthma (BA) on manifestations of oxidative stress and conditions of the antioxidant system (AOS). The need of correction of selenium deficit in BA-patients is determined by increased requirements in antioxidants due to chronic inflammatory process responsible for pathogenesis of BA. Latvia as well as Eastern Finland, Byelorussia, some regions of Ukraine, North-Western Russia, and New Zealand belong to the endemic areas with marked selenium deficit in soils and foodstuff. Twenty patients (7 men and 13 women) with selenium deficit and verified diagnosis of BA have been examined. In addition to basic therapy all patients received organic selenium as SelenoPRECISE (PharmaNord) 200 üg daily for 16 weeks. This caused statistically significant increase of plasma selenium from 50.94 ± 7.58 to 63.59 ± 10.87 μg/l (p < 0.001), the increase of selenium-dependent glutathione peroxidase (from 38.64 ± 10.72 U/g Hb to 58.57 ± 14.64 U/g Hb, p = 0.01). Treatment of patients with selenium also normalized the parameters characterizing oxidative stress (chemiluminescence), significantly exceeded normal values before this treatment. The use of selenium in addition to basic therapy allows to abolish or reduce oxidative stress by correcting the antioxidant system.

AB - The goal of this study was to investigate the effect of selenium deficit replenishment in patients with bronchial asthma (BA) on manifestations of oxidative stress and conditions of the antioxidant system (AOS). The need of correction of selenium deficit in BA-patients is determined by increased requirements in antioxidants due to chronic inflammatory process responsible for pathogenesis of BA. Latvia as well as Eastern Finland, Byelorussia, some regions of Ukraine, North-Western Russia, and New Zealand belong to the endemic areas with marked selenium deficit in soils and foodstuff. Twenty patients (7 men and 13 women) with selenium deficit and verified diagnosis of BA have been examined. In addition to basic therapy all patients received organic selenium as SelenoPRECISE (PharmaNord) 200 üg daily for 16 weeks. This caused statistically significant increase of plasma selenium from 50.94 ± 7.58 to 63.59 ± 10.87 μg/l (p < 0.001), the increase of selenium-dependent glutathione peroxidase (from 38.64 ± 10.72 U/g Hb to 58.57 ± 14.64 U/g Hb, p = 0.01). Treatment of patients with selenium also normalized the parameters characterizing oxidative stress (chemiluminescence), significantly exceeded normal values before this treatment. The use of selenium in addition to basic therapy allows to abolish or reduce oxidative stress by correcting the antioxidant system.

KW - Bronchial asthma

KW - Inflammation

KW - Oxidative stress

KW - Selenium

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U2 - 10.1134/S1990750808020108

DO - 10.1134/S1990750808020108

M3 - Article

AN - SCOPUS:44449170377

SN - 1990-7508

VL - 2

SP - 189

EP - 193

JO - Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry

JF - Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry

IS - 2

ER -

Assessment of some oxidative stress parameters in patients with bronchial asthma after selenium supplementation

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