TY - JOUR
T1 - Association between 4q25 variants, risk of atrial fibrillation and echocardiographic parameters
AU - Rudaka, Irina
AU - Rots, Dmitrijs
AU - Uzars, Arturs
AU - Kalējs, Oskars
AU - Gailîte, Linda
N1 - Funding Information:
The research was carried out with the financial support of Rîga Stradiòð University and Roche Academy Latvia.
Publisher Copyright:
© 2020 Sciendo. All rights reserved.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/2/1
Y1 - 2020/2/1
N2 - Atrial fibrillation (AF), the most common type of arrhythmia, has a heritable component. Variants at locus 4q25 are best associated with the risk of AF development in genome-wide association studies. Left atrial volume is an independent predictor of recurrence of AF after successful sinus rhythm restoration. The aim of our study was to investigate potential association between genetic variants at 4q25 locus and the risk of AF and echocardiographic parameters. We included 241 AF patients and 119 control individuals into the study. Left ventricle ejection fraction (LVEF, %) and left atrial volume index (LAVI, ml/m2) were assessed by transthoracic echocardiography during outpatient visits. We selected five 4q25 genetic variants (rs6825911, rs1126483, rs10004516, rs6838973, rs2200733) for the analysis. Variant rs6838973 was found to be associated with reduced risk of AF in additive (CCTT) and dominant (CC vs. CT+TT) models of inheritance. On the other hand, additive (CC<CT<TT) and dominant (CC vs. CT+TT) models of rs2200733 were associated with greater risk of AF. The same variations were found to be associated with age of AF onset. Median LAVI was 39.0 ml/m2 (IQR = 10.0) and median LVEF was 56.0% (IQR = 13.0). Statistically significant association was observed only between LAVI and variant rs1126483 in the dominant model of inheritance (median LAVI in CC vs. CT+TT – 38 ml/m2 vs. 40 ml/m2, U = 1602.5, p = 0.032). No significant association was found for LVEF and the analysed genotypes.
AB - Atrial fibrillation (AF), the most common type of arrhythmia, has a heritable component. Variants at locus 4q25 are best associated with the risk of AF development in genome-wide association studies. Left atrial volume is an independent predictor of recurrence of AF after successful sinus rhythm restoration. The aim of our study was to investigate potential association between genetic variants at 4q25 locus and the risk of AF and echocardiographic parameters. We included 241 AF patients and 119 control individuals into the study. Left ventricle ejection fraction (LVEF, %) and left atrial volume index (LAVI, ml/m2) were assessed by transthoracic echocardiography during outpatient visits. We selected five 4q25 genetic variants (rs6825911, rs1126483, rs10004516, rs6838973, rs2200733) for the analysis. Variant rs6838973 was found to be associated with reduced risk of AF in additive (CCTT) and dominant (CC vs. CT+TT) models of inheritance. On the other hand, additive (CC<CT<TT) and dominant (CC vs. CT+TT) models of rs2200733 were associated with greater risk of AF. The same variations were found to be associated with age of AF onset. Median LAVI was 39.0 ml/m2 (IQR = 10.0) and median LVEF was 56.0% (IQR = 13.0). Statistically significant association was observed only between LAVI and variant rs1126483 in the dominant model of inheritance (median LAVI in CC vs. CT+TT – 38 ml/m2 vs. 40 ml/m2, U = 1602.5, p = 0.032). No significant association was found for LVEF and the analysed genotypes.
KW - Arrhythmia
KW - Common genetic variants
KW - Echocardiography
KW - ENPEP
KW - PITX2
UR - http://www.scopus.com/inward/record.url?scp=85090011141&partnerID=8YFLogxK
U2 - 10.2478/prolas-2020-0001
DO - 10.2478/prolas-2020-0001
M3 - Article
AN - SCOPUS:85090011141
SN - 2255-890X
VL - 74
SP - 1
EP - 6
JO - Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.
JF - Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.
IS - 1
ER -