Association between the transmembrane region polymorphism of MHC class I chain related gene-A and type 1 diabetes mellitus in Sweden

Manu Gupta, Liene Nikitina-Zake, Marjan Zarghami, Mona Landin-Olsson, Ingrid Kockum, Åke Lernmark, Carani B. Sanjeevi

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

Major histocompatibility complex (MHC) class I chain related gene-A (MIC-A) is associated with type 1 diabetes mellitus (T1DM) in other populations. We tested the association of MIC-A gene polymorphism with T1DM in Swedish Caucasians; if it has an age-dependent association; and if the association has an effect on gender. We studied 635 T1DM patients and 503 matched controls in the age group of 0-35 years old. MIC-A5 was significantly increased in T1DM compared with controls (odds ratio [OR] =1.81, pc < 0.0005). Logistic regression analysis revealed MIC-A5 association was independent of HLA. MIC-A5 with DR4-DQ8 or MIC-A5 with DR3-DQ2 gave higher OR than the OR obtained with either of them alone (OR = 1.81, 7.1, and 3.6, respectively). MIC-A5 was positively (OR = 2.48, pc < 0.0005) and MIC-A6 negatively associated (OR = 0.61, pc = 0.035) with the disease in ≤ 20 years of age. The negative association of MIC-A6 in young onset was confirmed by logistic regression analysis. MIC-A5 was associated with the disease in males (OR = 2.05, pc = 0.0005). MIC-A6 conferred protection (OR = 0.098, pc = 0.032) in females heterozygous for DR3/DR4. In conclusion, MIC-A5 is associated with T1DM; the association was higher in individuals ≤ 20 years old; and negative association of MIC-A6 was stronger in younger onset patients than in older onset patients.

Original languageEnglish
Pages (from-to)553-561
Number of pages9
JournalHuman Immunology
Volume64
Issue number5
DOIs
Publication statusPublished - 1 May 2003
Externally publishedYes

Keywords*

  • Age
  • Autoimmune disease
  • Gender
  • HLA
  • Swedish population

Field of Science*

  • 1.6 Biological sciences
  • 3.1 Basic medicine
  • 3.2 Clinical medicine

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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