Association of Arterial Stiffness With Chronic Kidney Disease Progression and Mortality

Julija G. Voicehovska (Coresponding Author), Eva Bormane, Anda Grigane, Georgijs Moisejevs, Eva Moreino, Dace Trumpika, Vladimirs V. Voicehovskis

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

Chronic kidney disease (CKD) is a major public health concern. Despite many potentially life-threatening conditions that can accompany kidney disease, cardiovascular disease (CVD) remains the leading cause of death in these patients. Adjusted-for-age mortality from CVD in patients with end-stage renal disease is 10–30 times higher than in the general population. A decrease in renal function accelerates the development of cardiac pathology. Simultaneous exposure of CVD and CKD plays an important role in the relationship between arterial stiffness (AS) and estimated glomerular filtration rate. But there is a controversy as to whether the AS causes deterioration in kidney function, if renal dysfunction leads to AS, or the relationship is reciprocal. Hence, several studies that recruited high-risk populations reached a conclusion that comorbidities might lead to both AS and decline in kidney function over time. A number of studies have shown that several markers of AS, such as pulse pressure, central and peripheral pressure are associated with the development of CKD. This review takes into account the theoretical background, current status, and future potential of the techniques that measure AS within context of CKD assessment and management.

Original languageEnglish
Pages (from-to)1694-1701
JournalHeart Lung and Circulation
Volume30
Issue number11
DOIs
Publication statusPublished - Nov 2021

Keywords*

  • Arterial stiffness
  • Chronic kidney disease
  • CV risk prediction
  • Mortality
  • Prognosis
  • Vascular ageing

Field of Science*

  • 3.2 Clinical medicine

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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