Projects per year
Abstract
Forecasting the progression of the disease in the early inflammatory stage of the most prevalent type of multiple sclerosis (MS), referred to as relapsing–remitting multiple sclerosis (RRMS), is essential for making prompt treatment modifications, aimed to reduce clinical relapses and disability. In total, 58 patients with RRMS, having an Expanded Disability Status Scale (EDSS) score less than 4, were included in this study. Baseline magnetic resonance imaging (MRI) was performed, and brain and spinal cord lesions were evaluated. The disability of the patients was evaluated using EDSS at baseline and follow-up; enzyme-linked immunosorbent assays (ELISAs) were also used to determine the level of blood-based inflammation markers in plasma at baseline. The main results demonstrated that the baseline level of LBP was correlated with an increase in EDSS in a short (8–10 months) follow-up period. Furthermore, the prognostic significance of LBP was only observed in patients who received disease-modifying treatment (DMT) before the study. Our results suggest that the baseline level of LBP may be among the predictors of disability progression in RRMS over short follow-up periods, particularly in those receiving treatment. It highlights the effect of endotoxins in the pathogenesis of RRMS.
Original language | English |
---|---|
Article number | 298 |
Journal | International Journal of Molecular Sciences |
Volume | 26 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jan 2025 |
Keywords*
- Multiple Sclerosis
- Relapsing-Remitting/drug therapy
Field of Science*
- 3.1 Basic medicine
- 3.2 Clinical medicine
- 1.6 Biological sciences
Publication Type*
- 1.1. Scientific article indexed in Web of Science and/or Scopus database
Fingerprint
Dive into the research topics of 'Association of Baseline Lipopolysaccharide-Binding Protein with Expanded Disability Status Score Dynamics in Patients with Relapsing–Remitting Multiple Sclerosis: A Pilot Study'. Together they form a unique fingerprint.Projects
- 1 Finished
-
State research project in the field of biomedicine, medical technologies and pharmacy
Lejnieks, A. (Partner's coordinator), Karelis, G. (Leading expert), Gardovska, D. (Leading expert), Ābola, Z. (Leading expert), Miklaševičs, E. (Leading expert), Daneberga, Z. (Leading expert), Gardovskis, J. (Leading expert), Pētersons, A. (Leading expert), Kļaviņš, K. (Expert), Kroiča, J. (Leading expert), Skadiņš, I. (Leading expert), Vīksna, L. (Leading expert), Dimiņa, E. (Expert), Sniedze, D. (Participant), Karlsons, J. (Participant), Broks, R. (Participant), Gravele, D. (Expert), Rozentālberga, A. (Expert), Kanašniece, E. (Expert), Konrāde, I. (Leading expert), Trušinskis, K. (Leading expert), Strēle, I. (Leading expert), Kaļiņins, A. (Expert), Ķīvīte-Urtāne, A. (Leading expert), Radziņš, O. (Expert), Bāgante, I. (Leading expert), Koļesova, O. (Leading expert), Nora-Krūkle, Z. (Leading expert), Koļesovs, A. (Expert), Mičule, M. (Participant), Grāvelsiņa, S. (Expert), Rasa-Dzelzkalēja, S. (Leading expert), Kande, L. (Expert), Nakazawa (Miklasevica), M. (Leading expert), Vjaters, E. (Leading expert), Lietuvietis, V. (Leading expert), Plonis, J. (Leading expert), Bitiņa-Barlote, Ē. (Expert), Ieviņa, L. (Participant), Fortūna, K. (Expert (PhD student)), Pētersons, A. (Participant), Pastare, D. (Expert), Pugovičs, O. (Project leader), Silina, S. (Participant), Zemčugova-Bērziņa, A. (Participant), Tihomirova, Ļ. (Participant), Maļina, L. (Participant) & Kozačenko, J. (Participant)
1/12/22 → 30/11/24
Project: National Research Programme