ASSOCIATION OF BRAIN MRI VOLUMETRY RESULTS WITH CHANGES IN EDSS AMONG PATIENTS WITH MULTIPLE SCLEROSIS DURING A 5-YEAR FOLLOW-UP

Sintija Strautmane, Arturs Balodis, Agnete Teivane, Dagnija Grabovska, Edgars Fišermans, Dāniels Urbanovičs, Edgars Naudiņš, Jānis Mednieks, Alīna Flintere-Flinte, Zanda Priede, Andrejs Millers, Madara Miķelsone, Maksims Zolovs

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Abstract

Objectives. To investigate the relation between brain volumetry results and EDSS among patients with
multiple sclerosis in relation to provided treatment during a 5-year period.
Materials and Methods. In total, 66 consecutive patients with confirmed MS were enrolled in a
retrospective cohort study, predominantly females, 62.1% (n = 41); 92.4% (n = 61) relapsing-remitting
MS, 7.6% (n = 5) secondary-progressive (SP) MS patients. The median age was 45 (interquartile range
(IQR) 37-49). All patients were evaluated clinically using EDSS and radiologically using FreeSurfer© 7.2.0
during a 5-year follow-up.
Results. Baseline EDSS ranged between 1 and 6 with a median of 1.5 (IQR 1.5-2.0), after 5 years EDSS
went between 1 and 7, median of 3.0 (IQR 2.4–3.6), p < 0.05. During a 5-year period, EDSS increased in
86.4% (n = 47) patients with a significant increase among SPMS patients (median 7.0; IQR 5.0–7.0), compared
with RRMS patients (median 2.5; IQR 2.0–3.3), p < 0.001. Significantly lower volumetry results were obtained
in different brain areas including cortical and total grey and white matter, p < 0.05, with the most significant
decrease in the left thalamus (p = 0.001) and right thalamus, p < 0.001. Most patients received specific therapy
97.0% (n = 64). All patient EDSS increased, the most significant rise noted in patients receiving 1 st and 2 nd
line therapy, p < 0.001. In our study population, provided treatment did not influence volumetry results
during a 5-year follow-up, p > 0.05.
Conclusions. Brain magnetic resonance volumetry results are significantly associated with disability
progression. In our study, the most significant decrease was noted in the left and right thalamus. Therapy
did not influence volumetry changes. Further studies with larger patient groups are warranted to determine
the association between brain volume changes and MS patient disability progression in relation to the
provided treatment.
Original languageEnglish
Pages (from-to)233
Number of pages1
JournalMedicina (Kaunas)
Volume59
Issue numberSuppl.2
Publication statusPublished - 29 Mar 2023
EventInternational Scientific Conferences on Medicine & Public Health: Research Week 2023 Rīga Stradiņš University: Research Week 2023 Rīga Stradiņš University - Riga, Latvia
Duration: 27 Mar 202331 Mar 2023

Keywords*

  • EDSS
  • multiple sclerosis
  • magnetic resonance imaging
  • brain volumetry
  • atrophy

Field of Science*

  • 3.2 Clinical medicine

Publication Type*

  • 3.4. Other publications in conference proceedings (including local)

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