Abstract
Objectives. To investigate the relation between brain volumetry results and EDSS among patients with
multiple sclerosis in relation to provided treatment during a 5-year period.
Materials and Methods. In total, 66 consecutive patients with confirmed MS were enrolled in a
retrospective cohort study, predominantly females, 62.1% (n = 41); 92.4% (n = 61) relapsing-remitting
MS, 7.6% (n = 5) secondary-progressive (SP) MS patients. The median age was 45 (interquartile range
(IQR) 37-49). All patients were evaluated clinically using EDSS and radiologically using FreeSurfer© 7.2.0
during a 5-year follow-up.
Results. Baseline EDSS ranged between 1 and 6 with a median of 1.5 (IQR 1.5-2.0), after 5 years EDSS
went between 1 and 7, median of 3.0 (IQR 2.4–3.6), p < 0.05. During a 5-year period, EDSS increased in
86.4% (n = 47) patients with a significant increase among SPMS patients (median 7.0; IQR 5.0–7.0), compared
with RRMS patients (median 2.5; IQR 2.0–3.3), p < 0.001. Significantly lower volumetry results were obtained
in different brain areas including cortical and total grey and white matter, p < 0.05, with the most significant
decrease in the left thalamus (p = 0.001) and right thalamus, p < 0.001. Most patients received specific therapy
97.0% (n = 64). All patient EDSS increased, the most significant rise noted in patients receiving 1 st and 2 nd
line therapy, p < 0.001. In our study population, provided treatment did not influence volumetry results
during a 5-year follow-up, p > 0.05.
Conclusions. Brain magnetic resonance volumetry results are significantly associated with disability
progression. In our study, the most significant decrease was noted in the left and right thalamus. Therapy
did not influence volumetry changes. Further studies with larger patient groups are warranted to determine
the association between brain volume changes and MS patient disability progression in relation to the
provided treatment.
multiple sclerosis in relation to provided treatment during a 5-year period.
Materials and Methods. In total, 66 consecutive patients with confirmed MS were enrolled in a
retrospective cohort study, predominantly females, 62.1% (n = 41); 92.4% (n = 61) relapsing-remitting
MS, 7.6% (n = 5) secondary-progressive (SP) MS patients. The median age was 45 (interquartile range
(IQR) 37-49). All patients were evaluated clinically using EDSS and radiologically using FreeSurfer© 7.2.0
during a 5-year follow-up.
Results. Baseline EDSS ranged between 1 and 6 with a median of 1.5 (IQR 1.5-2.0), after 5 years EDSS
went between 1 and 7, median of 3.0 (IQR 2.4–3.6), p < 0.05. During a 5-year period, EDSS increased in
86.4% (n = 47) patients with a significant increase among SPMS patients (median 7.0; IQR 5.0–7.0), compared
with RRMS patients (median 2.5; IQR 2.0–3.3), p < 0.001. Significantly lower volumetry results were obtained
in different brain areas including cortical and total grey and white matter, p < 0.05, with the most significant
decrease in the left thalamus (p = 0.001) and right thalamus, p < 0.001. Most patients received specific therapy
97.0% (n = 64). All patient EDSS increased, the most significant rise noted in patients receiving 1 st and 2 nd
line therapy, p < 0.001. In our study population, provided treatment did not influence volumetry results
during a 5-year follow-up, p > 0.05.
Conclusions. Brain magnetic resonance volumetry results are significantly associated with disability
progression. In our study, the most significant decrease was noted in the left and right thalamus. Therapy
did not influence volumetry changes. Further studies with larger patient groups are warranted to determine
the association between brain volume changes and MS patient disability progression in relation to the
provided treatment.
| Original language | English |
|---|---|
| Pages (from-to) | 233 |
| Number of pages | 1 |
| Journal | Medicina (Kaunas) |
| Volume | 59 |
| Issue number | Suppl.2 |
| Publication status | Published - 29 Mar 2023 |
| Event | RSU Research Week 2023: Research Week 2023 Rīga Stradiņš University - Riga Stradins University, Riga, Latvia Duration: 27 Mar 2023 → 31 Mar 2023 https://rw2023.rsu.lv/general-information https://rw2023.rsu.lv |
Keywords*
- EDSS
- multiple sclerosis
- magnetic resonance imaging
- brain volumetry
- atrophy
Field of Science*
- 3.2 Clinical medicine
Publication Type*
- 3.4. Other publications in conference proceedings (including local)