HHV-6 un HHV-7 asociācija ar Gijēna – Barē sindromu

Translated title of the contribution: Association of HHV-6 and HHV-7 with Guillain-Barre Syndrome

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Background: There are many uncertainties concerning the etiological and other factors
determining the clinical course of chronic inflammatory and autoimmune diseases. Viral
infections can be one of them responsible for the onset and sustaining of these processes.
During the last few years much attention had been paid to the beta-herpesviruses demonstrating
that they are involved in the development of inflammatory and autoimmune diseases of CNS
and PNS. Very little is known about these viruses in clinical manifestation of Guillain-Barre
Syndrome (GBS) -an acute inflammatory demyelinating polyneuropathy, the etiology and
pathogenesis of which is still incompletely understood.
Aim: To evaluate the implication of human β-herpesviruses HHV-6, HHV-7 in acute
inflammatory processes in patients with GBS.
Patients and methods: 30 patients (16 men, 14 women; mean age 41 years) who fulfilled the
diagnostic criteria for GBS and 150 blood donors (73 men, 77 women; mean age 37 years) as
a control group were included in this observation.
Latent/persistent and active HHV-6 and HHV-7 infections were detected by nested PCR using
PBL and plasma DNA as the templates, respectively. Presence of viral mRNA in PBL was
examined by RT-PCR.
Results: PBL DNA of 11 (36.6%) patients showed the presence of HHV-6 genomic sequence
and DNA of 26 (86.6%) patients the presence of HHV-7 genomic sequence. No statistic
difference between the incidence of latent/persistent HHV-6 and HHV-7 infections in patients
with GBS and control group was found. The presence of HHV-6 genomic DNA in plasma was
shown in 3/11 (27.2%) patients (vs. 0/43 in blood donors, p<0.05), HHV-7 genomic sequence
in plasma DNA – in 11/26 (42.3%) patients (vs. 12/113; 10.6% in blood donors, p<0.05).
Conclusions: The correlation between HHV-6 and HHV-7 activation and GBS has been shown.
An implication of all beta-herpesviruses in GBS pathogenesis could not be excluded.
Translated title of the contributionAssociation of HHV-6 and HHV-7 with Guillain-Barre Syndrome
Original languageLatvian
Title of host publicationMedicīna
EditorsMāris Baltiņš
Place of PublicationRīga
PublisherLatvijas Universitāte
Pages68-73
Volume694
ISBN (Print)9984-783-28-6
Publication statusPublished - 2006

Publication series

NameLatvijas Universitātes raksti
ISSN (Print)1407-2157

Keywords*

  • HHV-6
  • HHV-7
  • latent/persistent infection
  • active infection
  • GBS

Field of Science*

  • 3.2 Clinical medicine

Publication Type*

  • 3.2. Articles or chapters in other proceedings other than those included in 3.1., with an ISBN or ISSN code

Fingerprint

Dive into the research topics of 'Association of HHV-6 and HHV-7 with Guillain-Barre Syndrome'. Together they form a unique fingerprint.

Cite this