Association of non-invasive markers of liver fibrosis with HCV coinfection and antiretroviral therapy in patients with HIV

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of this study was to assess the main effects and interaction between viral hepatitis C (HCV) coinfection and antiretroviral therapy (ART) by using a nonparametric ANOVA on direct and indirect markers of liver fibrosis in HIV-infected patients. The sample included 178 HIV patients aged from 23 to 65 (36% females). The following parameters were determined in blood of patients: hyaluronic acid, pro-matrix metalloproteinase-1, alanine aminotransferase, aspartate aminotransferase, and platelet count. The FIB-4 index was also calculated. The nonparametric ANOVA revealed no significant interaction between HCV coinfection and ART. This provides evidence for an independent contribution of each factor on promotion of the pathology. The results also demonstrated that the direct and indirect indicators of liver fibrosis are associated differently with the studied factors. Therefore, a combination of markers should be used for monitoring of liver fibrosis in HIV-infected patients.

Original languageEnglish
Pages (from-to)400-402
Number of pages3
JournalProceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences
Volume73
Issue number4
DOIs
Publication statusPublished - 1 Aug 2019

Keywords

  • ALT
  • AST
  • FIB-4
  • hyaluronic acid
  • liver fibrosis
  • nonparametric ANOVA
  • pro-MMP-1

Field of Science

  • 3.2 Clinical medicine
  • 3.3 Health sciences

Publication Type

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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