Association of non-invasive markers of liver fibrosis with HCV coinfection and antiretroviral therapy in patients with HIV

Oksana Koļesova; Jeļena Eglite; Aleksandrs Koļesovs; Angelika Krumiņa; Ilze Ekšteina; Monta Madelane; Ludmila Viksna

doi:10.2478/prolas-2019-0062

Association of non-invasive markers of liver fibrosis with HCV coinfection and antiretroviral therapy in patients with HIV

Oksana Koļesova, Jeļena Eglite, Aleksandrs Koļesovs, Angelika Krumiņa, Ilze Ekšteina, Monta Madelane, Ludmila Viksna

Department of Infectology

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Abstract

The aim of this study was to assess the main effects and interaction between viral hepatitis C (HCV) coinfection and antiretroviral therapy (ART) by using a nonparametric ANOVA on direct and indirect markers of liver fibrosis in HIV-infected patients. The sample included 178 HIV patients aged from 23 to 65 (36% females). The following parameters were determined in blood of patients: hyaluronic acid, pro-matrix metalloproteinase-1, alanine aminotransferase, aspartate aminotransferase, and platelet count. The FIB-4 index was also calculated. The nonparametric ANOVA revealed no significant interaction between HCV coinfection and ART. This provides evidence for an independent contribution of each factor on promotion of the pathology. The results also demonstrated that the direct and indirect indicators of liver fibrosis are associated differently with the studied factors. Therefore, a combination of markers should be used for monitoring of liver fibrosis in HIV-infected patients.

Original language	English
Pages (from-to)	400-402
Number of pages	3
Journal	Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences
Volume	73
Issue number	4
DOIs	https://doi.org/10.2478/prolas-2019-0062
Publication status	Published - 1 Aug 2019

Keywords*

ALT
AST
FIB-4
hyaluronic acid
liver fibrosis
nonparametric ANOVA
pro-MMP-1

Field of Science*

3.2 Clinical medicine
3.3 Health sciences

Publication Type*

1.1. Scientific article indexed in Web of Science and/or Scopus database

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2478/prolas-2019-0062

ASSOCIATION OF NON-INVASIVE MARKERS OF LIVERLicence: CC BY-NC-ND

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Koļesova, O., Eglite, J., Koļesovs, A., Krumiņa, A., Ekšteina, I., Madelane, M., & Viksna, L. (2019). Association of non-invasive markers of liver fibrosis with HCV coinfection and antiretroviral therapy in patients with HIV. Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences, 73(4), 400-402. https://doi.org/10.2478/prolas-2019-0062

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abstract = "The aim of this study was to assess the main effects and interaction between viral hepatitis C (HCV) coinfection and antiretroviral therapy (ART) by using a nonparametric ANOVA on direct and indirect markers of liver fibrosis in HIV-infected patients. The sample included 178 HIV patients aged from 23 to 65 (36% females). The following parameters were determined in blood of patients: hyaluronic acid, pro-matrix metalloproteinase-1, alanine aminotransferase, aspartate aminotransferase, and platelet count. The FIB-4 index was also calculated. The nonparametric ANOVA revealed no significant interaction between HCV coinfection and ART. This provides evidence for an independent contribution of each factor on promotion of the pathology. The results also demonstrated that the direct and indirect indicators of liver fibrosis are associated differently with the studied factors. Therefore, a combination of markers should be used for monitoring of liver fibrosis in HIV-infected patients.",

keywords = "ALT, AST, FIB-4, hyaluronic acid, liver fibrosis, nonparametric ANOVA, pro-MMP-1",

author = "Oksana Koļesova and Jeļena Eglite and Aleksandrs Koļesovs and Angelika Krumiņa and Ilze Ek{\v s}teina and Monta Madelane and Ludmila Viksna",

year = "2019",

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doi = "10.2478/prolas-2019-0062",

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pages = "400--402",

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Koļesova, O, Eglite, J, Koļesovs, A , Krumiņa, A, Ekšteina, I, Madelane, M & Viksna, L 2019, 'Association of non-invasive markers of liver fibrosis with HCV coinfection and antiretroviral therapy in patients with HIV', Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences, vol. 73, no. 4, pp. 400-402. https://doi.org/10.2478/prolas-2019-0062

Association of non-invasive markers of liver fibrosis with HCV coinfection and antiretroviral therapy in patients with HIV. / Koļesova, Oksana; Eglite, Jeļena; Koļesovs, Aleksandrs et al.
In: Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences, Vol. 73, No. 4, 01.08.2019, p. 400-402.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Association of non-invasive markers of liver fibrosis with HCV coinfection and antiretroviral therapy in patients with HIV

AU - Koļesova, Oksana

AU - Eglite, Jeļena

AU - Koļesovs, Aleksandrs

AU - Krumiņa, Angelika

AU - Ekšteina, Ilze

AU - Madelane, Monta

AU - Viksna, Ludmila

PY - 2019/8/1

Y1 - 2019/8/1

N2 - The aim of this study was to assess the main effects and interaction between viral hepatitis C (HCV) coinfection and antiretroviral therapy (ART) by using a nonparametric ANOVA on direct and indirect markers of liver fibrosis in HIV-infected patients. The sample included 178 HIV patients aged from 23 to 65 (36% females). The following parameters were determined in blood of patients: hyaluronic acid, pro-matrix metalloproteinase-1, alanine aminotransferase, aspartate aminotransferase, and platelet count. The FIB-4 index was also calculated. The nonparametric ANOVA revealed no significant interaction between HCV coinfection and ART. This provides evidence for an independent contribution of each factor on promotion of the pathology. The results also demonstrated that the direct and indirect indicators of liver fibrosis are associated differently with the studied factors. Therefore, a combination of markers should be used for monitoring of liver fibrosis in HIV-infected patients.

AB - The aim of this study was to assess the main effects and interaction between viral hepatitis C (HCV) coinfection and antiretroviral therapy (ART) by using a nonparametric ANOVA on direct and indirect markers of liver fibrosis in HIV-infected patients. The sample included 178 HIV patients aged from 23 to 65 (36% females). The following parameters were determined in blood of patients: hyaluronic acid, pro-matrix metalloproteinase-1, alanine aminotransferase, aspartate aminotransferase, and platelet count. The FIB-4 index was also calculated. The nonparametric ANOVA revealed no significant interaction between HCV coinfection and ART. This provides evidence for an independent contribution of each factor on promotion of the pathology. The results also demonstrated that the direct and indirect indicators of liver fibrosis are associated differently with the studied factors. Therefore, a combination of markers should be used for monitoring of liver fibrosis in HIV-infected patients.

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KW - AST

KW - FIB-4

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JF - Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences

IS - 4

ER -

Association of non-invasive markers of liver fibrosis with HCV coinfection and antiretroviral therapy in patients with HIV

Abstract

Keywords*

Field of Science*

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