Association of NT-proANP Level in Plasma and Humor Aqueous with Primary Open-Angle Glaucoma

Kristine Baumane, Renate Ranka, Guna Laganovska

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Purpose: The aim of this study is to determine differences in the levels of NT-proANP in the plasma and aqueous humor of glaucoma and cataract patients and to evaluate whether any relationships are present. Methods: The study group consisted of 58 patients with primary-open glaucoma (POAG) undergoing trabeculectomy surgery. The control group was comprised of 32 age-matched cataract patients. The concentration of the N-terminal fragment of the proatrial natriuretic peptide (NT-proANP, 1-98) in the aqueous humor and blood plasma samples was measured using an immunochemical method (ELISA). Results: The plasma NT-proANP concentration was significantly increased in patients with POAG compared to that in the control group (7.00 vs. 4.65 nmol/L, P = 0.0054). Similarly, the NT-proANP concentration in the aqueous humor was significantly higher in the POAG patients (0.47 vs. 0.09 nmol/L, P = 0.0112). However, there was no correlation between the NT-proANP values in the aqueous humor and the plasma of the POAG patients, as well as between the NT-proANP values in the aqueous humor and the intraocular pressure. Conclusions: We identified an association between the levels of NT-proANP in the plasma and the aqueous humor with POAG. Our data support the idea of the involvement of NP system in the development of POAG and highlight ANP as a possible biomarker of glaucoma.

Original languageEnglish
Pages (from-to)233-236
Number of pages4
JournalCurrent Eye Research
Volume42
Issue number2
DOIs
Publication statusPublished - 1 Feb 2017

Keywords

  • aqueous humor
  • Atrial natriuretic peptide
  • glaucoma
  • surgery
  • vascular factor

Field of Science

  • 3.2 Clinical medicine

Publication Type

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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