Abstract
Introduction.
Cancers of ovary represent about 30% of all malignancies of the female genital organs (K. R. Lee et al., 2003), but multiple myeloma (MM) is the 2nd most common haematological malignancy. In approximately 3% of MM there is absence of an M-protein (R.R. McKenna et al., 2007). In 2004 Bermejo et al. found familial association of some ovarian malignancies with MM.
The aim of our study is to demonstrate rare case with two different malignant neoplasms of different localization Materials and Methods. Clinical data were obtained from Riga Eastern Clinical University Hospital’s Oncology and Haematology Centres. Morphology was evaluated with haematoxylin/ eosin, PAS, Masson-Trichrome, Giemsa,
Gordon reticulin and Congo-red. Immunohistochemistry staining was done with kappa, lambda, CD 138, CD 20, LCA, BCL2, CyclinD1, CD 56, Cytokeratin 7 & 20, p53 antibodies.
Results.
66-years-old woman was admitted at hospital due to claviclular fracture. Laboratory tests: haemoglobin was 107 g/dL), normal ß2-microglobulin (1.53 mg/L), creatinine (54 μmol/L) and calcium (2.44 mmol/L) levels. M-gradient in the blood and urine were not detected. IgG and IgA levels were normal.
Bone marrow biopsy was characterized by hypercellularity (70%). Haemopoetic cells were subtotally replaced by small and medium sized plasma cells (CD 138+, 50-75%) with atypical changes: round or oval hyperchromic nuclei, some cells - small nucleoli.They have high nuclear/cytoplasm ratio (5-7:1).
Plasma cells' immunophenotype was with overexpression of lambda+, CD 56+, p53+, BCL2+ and Cyclin D1, but was negative with CD 20 & Kappa. Clinical diagnosis was nonsecretory MM. 4 years ago the same patient had surgery due to ovarian carcinoma (CA125 level was 255 U/ml). Histological diagnosis wasovarian bilateral Grade II serous papillary adenocarcinoma with multiple metastases in large omentum (1-2 cm Ø).
Adenocarcinoma expressed Cytokeratin7 and was negative with Cytokeratin 20. Stage was T3bNxMoG2 or IIIB FIGO.The patient has received course of chemotherapy.
Conclusion.
The presence of one malignant tumour, especially ovarian carcinoma, does not exclude the development of another one due to chemotherapyor due to unstable genetic changes Persons with double malignancies must havefamily control.
Cancers of ovary represent about 30% of all malignancies of the female genital organs (K. R. Lee et al., 2003), but multiple myeloma (MM) is the 2nd most common haematological malignancy. In approximately 3% of MM there is absence of an M-protein (R.R. McKenna et al., 2007). In 2004 Bermejo et al. found familial association of some ovarian malignancies with MM.
The aim of our study is to demonstrate rare case with two different malignant neoplasms of different localization Materials and Methods. Clinical data were obtained from Riga Eastern Clinical University Hospital’s Oncology and Haematology Centres. Morphology was evaluated with haematoxylin/ eosin, PAS, Masson-Trichrome, Giemsa,
Gordon reticulin and Congo-red. Immunohistochemistry staining was done with kappa, lambda, CD 138, CD 20, LCA, BCL2, CyclinD1, CD 56, Cytokeratin 7 & 20, p53 antibodies.
Results.
66-years-old woman was admitted at hospital due to claviclular fracture. Laboratory tests: haemoglobin was 107 g/dL), normal ß2-microglobulin (1.53 mg/L), creatinine (54 μmol/L) and calcium (2.44 mmol/L) levels. M-gradient in the blood and urine were not detected. IgG and IgA levels were normal.
Bone marrow biopsy was characterized by hypercellularity (70%). Haemopoetic cells were subtotally replaced by small and medium sized plasma cells (CD 138+, 50-75%) with atypical changes: round or oval hyperchromic nuclei, some cells - small nucleoli.They have high nuclear/cytoplasm ratio (5-7:1).
Plasma cells' immunophenotype was with overexpression of lambda+, CD 56+, p53+, BCL2+ and Cyclin D1, but was negative with CD 20 & Kappa. Clinical diagnosis was nonsecretory MM. 4 years ago the same patient had surgery due to ovarian carcinoma (CA125 level was 255 U/ml). Histological diagnosis wasovarian bilateral Grade II serous papillary adenocarcinoma with multiple metastases in large omentum (1-2 cm Ø).
Adenocarcinoma expressed Cytokeratin7 and was negative with Cytokeratin 20. Stage was T3bNxMoG2 or IIIB FIGO.The patient has received course of chemotherapy.
Conclusion.
The presence of one malignant tumour, especially ovarian carcinoma, does not exclude the development of another one due to chemotherapyor due to unstable genetic changes Persons with double malignancies must havefamily control.
| Original language | English |
|---|---|
| Pages | 20-21 |
| Number of pages | 32 |
| Publication status | Published - 2017 |
| Event | 24th Baltic-German Symposion for Pathology of the German Division of IAP and 6th Symposium of the Baltic IAP Division - Riga, Latvia Duration: 25 Jan 2017 → 27 Jan 2017 Conference number: 24 https://www.lu.lv/fileadmin/user_upload/lu_portal/zinas/2017/maijs/24th_Baltic-German_Symposion_for_Pathology_.pdf |
Symposium
| Symposium | 24th Baltic-German Symposion for Pathology of the German Division of IAP and 6th Symposium of the Baltic IAP Division |
|---|---|
| Country/Territory | Latvia |
| City | Riga |
| Period | 25/01/17 → 27/01/17 |
| Internet address |
Keywords*
- myeloma
- ovarian cancer
- Adenocarcinoma
Field of Science*
- 3.1 Basic medicine
- 3.2 Clinical medicine
Publication Type*
- 3.4. Other publications in conference proceedings (including local)
