Association of reduced glyoxalase 1 activity and painful peripheral diabetic neuropathy in type 1 and 2 diabetes mellitus patients

Elina Skapare; Ilze Konrade; Edgars Liepinsh; Ieva Strele; Marina Makrecka; Angelika Bierhaus; Aivars Lejnieks; Valdis Pirags; Maija Dambrova

doi:10.1016/j.jdiacomp.2012.12.002

Association of reduced glyoxalase 1 activity and painful peripheral diabetic neuropathy in type 1 and 2 diabetes mellitus patients

Elina Skapare, Ilze Konrade, Edgars Liepinsh, Ieva Strele, Marina Makrecka, Angelika Bierhaus, Aivars Lejnieks, Valdis Pirags, Maija Dambrova

Faculty of Pharmacy

Research output: Contribution to journal › Article › peer-review

49 Citations (Scopus)

Abstract

Aims: The present study was undertaken to investigate the relationship between glyoxalase 1 (Glo1) enzyme activity and painful diabetic neuropathy (DN) in patients with diabetes mellitus. Methods Glo1 activity and biochemical markers were determined in blood samples from 108 patients with type 1 diabetes, 109 patients with type 2 diabetes, and 132 individuals without diabetes as a control. Painful and painless peripheral DN was assessed and multivariate regression analysis was used to determine independent association of Glo1 activity with occurrence of painful DN. Results In patients with type 1 and type 2 diabetes mellitus and painful DN compared to patients with painless DN, Glo1 activity was significantly reduced by 12 and 14%, respectively. The increase in Glo1 activity was significantly associated with reduced occurrence of painful DN after adjusting for confounders by multivariate analysis. Conclusions Our results demonstrate for the first time that Glo1 activity is lower in patients with both types of diabetes mellitus who were diagnosed with painful DN. These data support the hypothesis that Glo1 activity modulates the phenotype of DN and warrant further investigation into the role of Glo1 in DN.

Original language	English
Pages (from-to)	262-267
Number of pages	6
Journal	Journal of Diabetes and its Complications
Volume	27
Issue number	3
DOIs	https://doi.org/10.1016/j.jdiacomp.2012.12.002
Publication status	Published - May 2013

Keywords*

Diabetes mellitus
Glyoxalase 1
Painful diabetic neuropathy
Type 1 diabetes
Type 2 diabetes

Field of Science*

3.1 Basic medicine
3.2 Clinical medicine

Publication Type*

1.1. Scientific article indexed in Web of Science and/or Scopus database

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jdiacomp.2012.12.002

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@article{f46efd5012634f32881e5ef587077d6e,

title = "Association of reduced glyoxalase 1 activity and painful peripheral diabetic neuropathy in type 1 and 2 diabetes mellitus patients",

abstract = "Aims: The present study was undertaken to investigate the relationship between glyoxalase 1 (Glo1) enzyme activity and painful diabetic neuropathy (DN) in patients with diabetes mellitus. Methods Glo1 activity and biochemical markers were determined in blood samples from 108 patients with type 1 diabetes, 109 patients with type 2 diabetes, and 132 individuals without diabetes as a control. Painful and painless peripheral DN was assessed and multivariate regression analysis was used to determine independent association of Glo1 activity with occurrence of painful DN. Results In patients with type 1 and type 2 diabetes mellitus and painful DN compared to patients with painless DN, Glo1 activity was significantly reduced by 12 and 14%, respectively. The increase in Glo1 activity was significantly associated with reduced occurrence of painful DN after adjusting for confounders by multivariate analysis. Conclusions Our results demonstrate for the first time that Glo1 activity is lower in patients with both types of diabetes mellitus who were diagnosed with painful DN. These data support the hypothesis that Glo1 activity modulates the phenotype of DN and warrant further investigation into the role of Glo1 in DN.",

keywords = "Diabetes mellitus, Glyoxalase 1, Painful diabetic neuropathy, Type 1 diabetes, Type 2 diabetes",

author = "Elina Skapare and Ilze Konrade and Edgars Liepinsh and Ieva Strele and Marina Makrecka and Angelika Bierhaus and Aivars Lejnieks and Valdis Pirags and Maija Dambrova",

note = "Funding Information: This study was supported by the European Foundation for the Study of Diabetes (EFSD) grant programme New Horizons Collaborative Research Initiative, the European Social Fund agreement No.009/0147/1DP/1.1.2.1.2/09/IPIA/VIAA/009 and the Latvian State Research Programme BIOMEDICINE. We thank T. Fleming (University of Heidelberg, Department of Medicine I and Clinical Chemistry, Germany) for scientific advice and sharing unpublished results. We thank E. Loza, O. Pugovics and S. Grinberga for methylgyoxal quantification (Latvian Institute of Organic Synthesis, Latvia). Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

year = "2013",

month = may,

doi = "10.1016/j.jdiacomp.2012.12.002",

language = "English",

volume = "27",

pages = "262--267",

journal = "Journal of Diabetes and its Complications",

issn = "1056-8727",

publisher = "Elsevier Inc.",

number = "3",

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TY - JOUR

T1 - Association of reduced glyoxalase 1 activity and painful peripheral diabetic neuropathy in type 1 and 2 diabetes mellitus patients

AU - Skapare, Elina

AU - Konrade, Ilze

AU - Liepinsh, Edgars

AU - Strele, Ieva

AU - Makrecka, Marina

AU - Bierhaus, Angelika

AU - Lejnieks, Aivars

AU - Pirags, Valdis

AU - Dambrova, Maija

N1 - Funding Information: This study was supported by the European Foundation for the Study of Diabetes (EFSD) grant programme New Horizons Collaborative Research Initiative, the European Social Fund agreement No.009/0147/1DP/1.1.2.1.2/09/IPIA/VIAA/009 and the Latvian State Research Programme BIOMEDICINE. We thank T. Fleming (University of Heidelberg, Department of Medicine I and Clinical Chemistry, Germany) for scientific advice and sharing unpublished results. We thank E. Loza, O. Pugovics and S. Grinberga for methylgyoxal quantification (Latvian Institute of Organic Synthesis, Latvia). Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 2013/5

Y1 - 2013/5

N2 - Aims: The present study was undertaken to investigate the relationship between glyoxalase 1 (Glo1) enzyme activity and painful diabetic neuropathy (DN) in patients with diabetes mellitus. Methods Glo1 activity and biochemical markers were determined in blood samples from 108 patients with type 1 diabetes, 109 patients with type 2 diabetes, and 132 individuals without diabetes as a control. Painful and painless peripheral DN was assessed and multivariate regression analysis was used to determine independent association of Glo1 activity with occurrence of painful DN. Results In patients with type 1 and type 2 diabetes mellitus and painful DN compared to patients with painless DN, Glo1 activity was significantly reduced by 12 and 14%, respectively. The increase in Glo1 activity was significantly associated with reduced occurrence of painful DN after adjusting for confounders by multivariate analysis. Conclusions Our results demonstrate for the first time that Glo1 activity is lower in patients with both types of diabetes mellitus who were diagnosed with painful DN. These data support the hypothesis that Glo1 activity modulates the phenotype of DN and warrant further investigation into the role of Glo1 in DN.

AB - Aims: The present study was undertaken to investigate the relationship between glyoxalase 1 (Glo1) enzyme activity and painful diabetic neuropathy (DN) in patients with diabetes mellitus. Methods Glo1 activity and biochemical markers were determined in blood samples from 108 patients with type 1 diabetes, 109 patients with type 2 diabetes, and 132 individuals without diabetes as a control. Painful and painless peripheral DN was assessed and multivariate regression analysis was used to determine independent association of Glo1 activity with occurrence of painful DN. Results In patients with type 1 and type 2 diabetes mellitus and painful DN compared to patients with painless DN, Glo1 activity was significantly reduced by 12 and 14%, respectively. The increase in Glo1 activity was significantly associated with reduced occurrence of painful DN after adjusting for confounders by multivariate analysis. Conclusions Our results demonstrate for the first time that Glo1 activity is lower in patients with both types of diabetes mellitus who were diagnosed with painful DN. These data support the hypothesis that Glo1 activity modulates the phenotype of DN and warrant further investigation into the role of Glo1 in DN.

KW - Diabetes mellitus

KW - Glyoxalase 1

KW - Painful diabetic neuropathy

KW - Type 1 diabetes

KW - Type 2 diabetes

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DO - 10.1016/j.jdiacomp.2012.12.002

M3 - Article

C2 - 23351995

AN - SCOPUS:84876937363

SN - 1056-8727

VL - 27

SP - 262

EP - 267

JO - Journal of Diabetes and its Complications

JF - Journal of Diabetes and its Complications

IS - 3

ER -

Association of reduced glyoxalase 1 activity and painful peripheral diabetic neuropathy in type 1 and 2 diabetes mellitus patients

Abstract

Keywords*

Field of Science*

Publication Type*

UN SDGs

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