TY - JOUR
T1 - Association of single nucleotide polymorphism in chromosome 11 with autism spectrum disorder
AU - Bauze, Daiga
AU - Piekuse, Linda
AU - Kevere, Laura
AU - Kronberga, Zane
AU - Riževs, Arnis
AU - Vaivade, Iveta
AU - Vīksne, Kristīne
AU - Andrēziņa, Raisa
AU - Lāce, Baiba
N1 - Funding Information:
This study was supported by the European Social Foundation (ESF), Project No. 2009/0147/1DP/1.1.2.1.2/09/IPIA/ VIAA/009. We are grateful to all the parents and children for their participation in this study.
Publisher Copyright:
Copyright © 2011-2014 by Walter de Gruyter GmbH.
PY - 2013/12/1
Y1 - 2013/12/1
N2 - Several genetic loci in chromosomes 11 and 15 have recently been associated with non-syndromic autism spectrum disorder (ASD) in populations from North America and Europe. The aim of the present study was to investigate whether such an association exists in a Latvian population. Ninety-five patients with ASD in the age range 3-20 years (mean age 8 years, SD 3.18) participated in the study. The control group consisted of 161 healthy, non-related individuals without ASD randomly selected from the Latvian Genome Database. Four single nucleotide polymorphisms (SNPs) - rs11212733, SNP rs1394119, rs2421826, rs1454985 - were genotyped by the TaqMan method. Allele frequency differences between ASD patients and control subjects were compared for each SNP using a standard chi-square test with Bonferroni correction. The level of statistical significance was set at 0.05 for nominal association. Only the genetic marker rs11212733, localised on the long arm of chromosome 11 in locus 22.3, was found to be strongly associated with the ASD patient group (X2 6.982, Padjusted 0.033, odds ratio 1.625). Our data demonstrating a significant relationship between the SNP rs11212733 and the development of ASD in a Latvian population suggest that it is not a population-specific relationship. Thus, future studies focusing on the DDX10 gene and related genetic loci are needed.
AB - Several genetic loci in chromosomes 11 and 15 have recently been associated with non-syndromic autism spectrum disorder (ASD) in populations from North America and Europe. The aim of the present study was to investigate whether such an association exists in a Latvian population. Ninety-five patients with ASD in the age range 3-20 years (mean age 8 years, SD 3.18) participated in the study. The control group consisted of 161 healthy, non-related individuals without ASD randomly selected from the Latvian Genome Database. Four single nucleotide polymorphisms (SNPs) - rs11212733, SNP rs1394119, rs2421826, rs1454985 - were genotyped by the TaqMan method. Allele frequency differences between ASD patients and control subjects were compared for each SNP using a standard chi-square test with Bonferroni correction. The level of statistical significance was set at 0.05 for nominal association. Only the genetic marker rs11212733, localised on the long arm of chromosome 11 in locus 22.3, was found to be strongly associated with the ASD patient group (X2 6.982, Padjusted 0.033, odds ratio 1.625). Our data demonstrating a significant relationship between the SNP rs11212733 and the development of ASD in a Latvian population suggest that it is not a population-specific relationship. Thus, future studies focusing on the DDX10 gene and related genetic loci are needed.
KW - Autism spectrum disorder (ASD)
KW - DDX10
KW - Rs11212733
KW - Single nucleotide polymorphisms (SNPs)
UR - http://www.scopus.com/inward/record.url?scp=84915820309&partnerID=8YFLogxK
U2 - 10.2478/prolas-2013-0079
DO - 10.2478/prolas-2013-0079
M3 - Article
AN - SCOPUS:84915820309
SN - 1407-009X
VL - 67
SP - 453
EP - 456
JO - Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences
JF - Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences
IS - 6
ER -