Introduction and objectives
The skin as a physical barrier coexists with the collection of bacteria, fungi and viruses that is part of the skin biome and play a crucial role for normal functioning. The pathogenesis of atopic dermatitis (AD) is multifactorial and nowadays, great interest has awakened its connection to dysbiosis. (Bjerre et al., 2017). Skin barrier dysfunction, increased synthesis of the extra cellular matrix adhesins and decreased antimicrobial peptides promote colonisation of bacteria. Staphylococcus aureus (S.aureus) appears to play a significant role as a worsenerofAD’sseverity. S.aureusproducesexotoxinsthataresuperantigensandmaypenetrateskinbarrier and can cause or exacerbate allergic skin inflammation (Cardona et al.,2006) Resistance to antimicrobial agentshasbecomeamajorsourceofinterestworldwide. Forthisreason,itiscrucialtounderstandthe antibacterial susceptibility and resistance in each region.
Materials and methods
The medical documentation, data of laboratory results were reviewed and statistically processed in the context of up-to-date medical literature.
Patients were selected from Rīga 1st Hospital, Clinical Centre of Skin and Sexually Transmitted Diseases (2019- 2021) with a confirmed diagnosis of atopic dermatitis (n = 76). After processing of the data and evaluation of the inclusion criteria were selected 63 patients (inclusion criteria: >18 years old, Skin culture test with a/b sensitivity, clinical findings (erythema, crusting, excoriations, oozing)). 58 of selected patients were isolated microorganisms.
Staphylococcus aureus was detected in 69% of patients with AD. Antibiotic analyses of the isolates revealed that the main resistance is to penicillin 65,9% of cases, followed by resistance to erythromycin in 2,4% and tetracycline in 2,4% of cases. Unsusceptibility to ciprofloxacin was in 87,8% cases.
Coagulase-negative S. aureus was detected in 20.4%, all detected microorganisms were unsusceptible to ciprofloxacin (100%) and 33,3% of them resistant to erythromycin, 16,6 % resistance to tetracycline followed by 8,3% resistance to trimethoprim/sulfamethoxazole, 8,3% to cefazoline and 8,3 % to ceftriaxone. Conclusions
As antimicrobial resistance is increasing, and it is essential to know regional antibacterial susceptibility and to target adequate antimicrobial therapy. It's possible that for Latvian’ patients with atopic dermatitis dominating microorganisms are Staphylococcus aureus and Coagulase-negative S. areas with resistance to ciprofloxacin and erythromycin respectively.
|Number of pages||1|
|Publication status||Published - Oct 2022|
|Event||18th Congress of the Baltic Association of Dermatovenerologists (BADV): Stronger together! - hybrid event, Riga, Latvia|
Duration: 22 Sept 2022 → 24 Sept 2022
Conference number: 18
|Congress||18th Congress of the Baltic Association of Dermatovenerologists (BADV)|
|Period||22/09/22 → 24/09/22|
- atopic dermatitis
- Antibacterial susceptibility
- microbial flora
Field of Science*
- 3.3 Health sciences
- 3.4. Other publications in conference proceedings (including local)