Autofluorescence imaging for recurrence detection in skin cancer postoperative scars

Mindaugas Tamošiūnas (Coresponding Author), Emilija V. Plorina, Marta Lange, Aleksandrs Derjabo, Ilona Kuzmina, Dmitrijs Bļizņuks, Janis Spigulis

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

This clinical study is a first attempt to use autofluorescence for recurrence diagnosis of skin cancer in postoperative scars. The proposed diagnostic parameter is based on a reduction in scar autofluorescence, evaluated in the green spectral channel. The validity of the method has been tested on 110 postoperative scars from 56 patients suspected of non-melanoma skin cancer, with eight patients (13 scars) available for the repeated examination. The recurrence diagnosis within a scar has been made after two subsequent autofluorescence check-ups, representing the temporal difference between the scar autofluorescence amplitudes as a vector. The recognition of recurrence has been discussed to represent the significant deviations from the value of vector angle θ. This new autofluorescence-based method can be easily integrated into the postoperative monitoring of surgical scars and can help diagnose the recurrence of skin cancer from the early stage of scar development.

Original languageEnglish
Article numbere201900162
Pages (from-to)e201900162
JournalJournal of Biophotonics
Volume13
Issue number3
DOIs
Publication statusPublished - 1 Mar 2020
Externally publishedYes

Keywords

  • autofluorescence imaging
  • recurrence
  • scar
  • skin cancer
  • surgery

Field of Science

  • 3.2 Clinical medicine
  • 1.3 Physical sciences

Publication Type

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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