Autofluorescence imaging of the skin is an objective non-invasive technique for diagnosing pseudoxanthoma elasticum

Klára Farkas, Szabolcs Bozsányi, Dóra Plázár, András Bánvölgyi, Luca Fésűs, Pálma Anker, Sára Zakariás, Ilze Lihacova, Alexey Lihachev, Marta Lange, Tamás Arányi, Norbert M. Wikonkál, Márta Medvecz, Norbert Kiss (Coresponding Author)

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)
1 Downloads (Pure)


Pseudoxanthoma elasticum (PXE) is a rare multisystemic autosomal recessive connective tissue disease. In most cases, skin manifestations of PXE are the first to develop, followed later by severe ocular and cardiovascular complications. In our present study, in addition to dermoscopy, we introduced novel techniques, autofluorescence (AF) and diffuse reflectance (DR) imaging for the assessment of affected skin sites of five PXE patients. PXE-affected skin areas in most skin sites showed a previously observed pattern upon dermoscopic examination. With the novel imaging, PXE-affected skin lesions displayed high AF intensity. During our measurements, significantly higher mean, minimum and maximum AF intensity values were found in areas of PXE-affected skin when compared to uninvolved skin. Conversely, images acquired with the use of 660 and 940 nm illumination showed no mentionable difference. Our results demonstrate that AF imaging may be used in the in vivo diagnostics and quantification of the severity of the skin lesions of PXE patients. In addition, it is a safe, fast and cost-effective diagnostic method. AF imaging may be also used to objectively monitor the efficacy of the possible novel therapeutic approaches of PXE in the future.

Original languageEnglish
Article number260
Issue number2
Publication statusPublished - 2021
Externally publishedYes


  • Autofluorescence imaging
  • Calcification
  • Dermoscopy
  • Diagnosis
  • Diffuse reflectance imaging
  • LED
  • Pseudoxanthoma elasticum
  • Quantitative analysis

Field of Science*

  • 1.3 Physical sciences
  • 1.4 Chemical sciences
  • 2.6 Medical engineering

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database


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