The physical, chemical and biological properties of both biphasic calcium phosphate (BCP) bioceramics and fibrin scaffolds may be cumulated for preparing advanced bone substitutes. Aim of experimental study was to evaluate histological response on implantation of synthetic biphasic HAp/TCP bioceramic granules mixed with autologous plasma derived fibrin scaffold in subcutaneous tissue of rabbits. Subcutaneus implantation of BCP granules with fibrin scaffold was performed in 6 experimental animals. BCP granules without fibrin scaffold were implanted on the control side. After 6 weeks tissues were prepared for detection of apoptosis using TUNEL method. Routine histological method - staining with hematoxilin and eosin and evaluating with Leica BME microscopy was used for obtaining a review picture. Routine histological examination after implantation of fibrin scaffold with BCP bioceramic granules showed increased number of cells, mainly plasmatic and gigantic cells also lymphocytes and eosinophils, pronounced angiogenesis and increased formation of fibrous tissue capsule compared with control side. From our results we can conclude that plasma derived fibrin scaffold activates encapsulation of BCP bioceramic in soft tissue environment. This phenomenon may serve as a possibility for biological retention of drugs, growth factors and/or cells.