Autologous fibrin mixed with biphasic calcium phosphate bioceramic granules activates encapsulation in soft tissue environment

I. Salma, G. Salms, A. Skagers, M. Pilmane, L. Feldmane

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review


The physical, chemical and biological properties of both biphasic calcium phosphate (BCP) bioceramics and fibrin scaffolds may be cumulated for preparing advanced bone substitutes. Aim of experimental study was to evaluate histological response on implantation of synthetic biphasic HAp/TCP bioceramic granules mixed with autologous plasma derived fibrin scaffold in subcutaneous tissue of rabbits. Subcutaneus implantation of BCP granules with fibrin scaffold was performed in 6 experimental animals. BCP granules without fibrin scaffold were implanted on the control side. After 6 weeks tissues were prepared for detection of apoptosis using TUNEL method. Routine histological method - staining with hematoxilin and eosin and evaluating with Leica BME microscopy was used for obtaining a review picture. Routine histological examination after implantation of fibrin scaffold with BCP bioceramic granules showed increased number of cells, mainly plasmatic and gigantic cells also lymphocytes and eosinophils, pronounced angiogenesis and increased formation of fibrous tissue capsule compared with control side. From our results we can conclude that plasma derived fibrin scaffold activates encapsulation of BCP bioceramic in soft tissue environment. This phenomenon may serve as a possibility for biological retention of drugs, growth factors and/or cells.

Original languageEnglish
Title of host publicationInternational Symposium on Biomedical Engineering and Medical Physics, ISBEMP 2012
Number of pages4
Publication statusPublished - 2013
EventInternational Symposium on Biomedical Engineering and Medical Physics - Riga, Latvia
Duration: 10 Oct 201212 Oct 2012

Publication series

NameIFMBE Proceedings
Volume38 IFMBE
ISSN (Print)1680-0737


SymposiumInternational Symposium on Biomedical Engineering and Medical Physics
Abbreviated titleISBEMP 2012


  • autologous plasma
  • calcium phosphate bioceramic
  • fibrin scaffold
  • in vivo experiments

Field of Science*

  • 2.6 Medical engineering
  • 3.1 Basic medicine
  • 3.2 Clinical medicine

Publication Type*

  • 3.1. Articles or chapters in proceedings/scientific books indexed in Web of Science and/or Scopus database


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