B cell contribution to immunometabolic dysfunction and impaired immune responses in obesity

Kristine Oleinika (Coresponding Author), Baiba Slisere, Diego Catalán, Elizabeth C. Rosser

Research output: Contribution to journalReview articlepeer-review

15 Citations (Scopus)
16 Downloads (Pure)

Abstract

Obesity increases the risk of type 2 diabetes mellitus, cardiovascular disease, fatty liver disease, and cancer. It is also linked with more severe complications from infections, including COVID-19, and poor vaccine responses. Chronic, low-grade inflammation and associated immune perturbations play an important role in determining morbidity in people living with obesity. The contribution of B cells to immune dysregulation and meta-inflammation associated with obesity has been documented by studies over the past decade. With a focus on human studies, here we consolidate the observations demonstrating that there is altered B cell subset composition, differentiation, and function both systemically and in the adipose tissue of individuals living with obesity. Finally, we discuss the potential factors that drive B cell dysfunction in obesity and propose a model by which altered B cell subset composition in obesity underlies dysfunctional B cell responses to novel pathogens.
Original languageEnglish
Pages (from-to)263-272
JournalClinical and Experimental Immunology
Volume210
Issue number3
DOIs
Publication statusPublished - Dec 2022

Field of Science*

  • 3.1 Basic medicine
  • 3.2 Clinical medicine

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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