Bad “Good” Bile Acids and Gut Microbiota Dysbiosis in Inflammatory Bowel Disease: Mice and Humans Are Not the Same

Stanislav Sitkin; Juris Pokrotnieks

doi:10.1007/s10620-020-06650-3

Bad “Good” Bile Acids and Gut Microbiota Dysbiosis in Inflammatory Bowel Disease: Mice and Humans Are Not the Same

Stanislav Sitkin (Corresponding Author), Juris Pokrotnieks

Department of Internal Diseases

Research output: Contribution to journal › Letter › peer-review

3 Citations (Scopus)

Abstract

The effects of deoxycholic acid (DCA) on the intestinal microbiota, bile acid (BA) metabolism, and intestinal epithelium can be influenced by various factors. Depending on the specific conditions, DCA can be “bad” (proinflammatory) or “good” (anti-inflammatory). Mouse models of colitis show an increase in conjugated BAs and gut dysbiosis, including DCA-related dysbiosis, with a significant decrease in bile salt hydrolase (bsh) gene-containing taxa. Human patients with inflammatory bowel disease demonstrate, primarily, a decrease in bile acid-inducible (bai) gene-containing taxa and a deficiency in secondary BAs, suggesting their anti-inflammatory role.

Original language	English
Pages (from-to)	925-927
Number of pages	3
Journal	Digestive Diseases and Sciences
Volume	66
Issue number	3
DOIs	https://doi.org/10.1007/s10620-020-06650-3
Publication status	Published - Mar 2021

Keywords*

Bile acids
Deoxycholic acid
Gut dysbiosis
Inflammatory bowel disease
Intestinal inflammation
Intestinal microbiome
Ulcerative colitis

Field of Science*

3.2 Clinical medicine

Publication Type*

1.1. Scientific article indexed in Web of Science and/or Scopus database

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s10620-020-06650-3

Cite this

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title = "Bad “Good” Bile Acids and Gut Microbiota Dysbiosis in Inflammatory Bowel Disease: Mice and Humans Are Not the Same",

abstract = "The effects of deoxycholic acid (DCA) on the intestinal microbiota, bile acid (BA) metabolism, and intestinal epithelium can be influenced by various factors. Depending on the specific conditions, DCA can be “bad” (proinflammatory) or “good” (anti-inflammatory). Mouse models of colitis show an increase in conjugated BAs and gut dysbiosis, including DCA-related dysbiosis, with a significant decrease in bile salt hydrolase (bsh) gene-containing taxa. Human patients with inflammatory bowel disease demonstrate, primarily, a decrease in bile acid-inducible (bai) gene-containing taxa and a deficiency in secondary BAs, suggesting their anti-inflammatory role.",

keywords = "Bile acids, Deoxycholic acid, Gut dysbiosis, Inflammatory bowel disease, Intestinal inflammation, Intestinal microbiome, Ulcerative colitis",

author = "Stanislav Sitkin and Juris Pokrotnieks",

year = "2021",

month = mar,

doi = "10.1007/s10620-020-06650-3",

language = "English",

volume = "66",

pages = "925--927",

journal = "Digestive Diseases and Sciences",

issn = "0163-2116",

publisher = "Springer",

number = "3",

}

TY - JOUR

T1 - Bad “Good” Bile Acids and Gut Microbiota Dysbiosis in Inflammatory Bowel Disease

T2 - Mice and Humans Are Not the Same

AU - Sitkin, Stanislav

AU - Pokrotnieks, Juris

PY - 2021/3

Y1 - 2021/3

N2 - The effects of deoxycholic acid (DCA) on the intestinal microbiota, bile acid (BA) metabolism, and intestinal epithelium can be influenced by various factors. Depending on the specific conditions, DCA can be “bad” (proinflammatory) or “good” (anti-inflammatory). Mouse models of colitis show an increase in conjugated BAs and gut dysbiosis, including DCA-related dysbiosis, with a significant decrease in bile salt hydrolase (bsh) gene-containing taxa. Human patients with inflammatory bowel disease demonstrate, primarily, a decrease in bile acid-inducible (bai) gene-containing taxa and a deficiency in secondary BAs, suggesting their anti-inflammatory role.

AB - The effects of deoxycholic acid (DCA) on the intestinal microbiota, bile acid (BA) metabolism, and intestinal epithelium can be influenced by various factors. Depending on the specific conditions, DCA can be “bad” (proinflammatory) or “good” (anti-inflammatory). Mouse models of colitis show an increase in conjugated BAs and gut dysbiosis, including DCA-related dysbiosis, with a significant decrease in bile salt hydrolase (bsh) gene-containing taxa. Human patients with inflammatory bowel disease demonstrate, primarily, a decrease in bile acid-inducible (bai) gene-containing taxa and a deficiency in secondary BAs, suggesting their anti-inflammatory role.

KW - Bile acids

KW - Deoxycholic acid

KW - Gut dysbiosis

KW - Inflammatory bowel disease

KW - Intestinal inflammation

KW - Intestinal microbiome

KW - Ulcerative colitis

UR - http://www.scopus.com/inward/record.url?scp=85092587896&partnerID=8YFLogxK

U2 - 10.1007/s10620-020-06650-3

DO - 10.1007/s10620-020-06650-3

M3 - Letter

AN - SCOPUS:85092587896

SN - 0163-2116

VL - 66

SP - 925

EP - 927

JO - Digestive Diseases and Sciences

JF - Digestive Diseases and Sciences

IS - 3

ER -

Bad “Good” Bile Acids and Gut Microbiota Dysbiosis in Inflammatory Bowel Disease: Mice and Humans Are Not the Same

Abstract

Keywords*

Field of Science*

Publication Type*

UN SDGs

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