Abstract
The effects of deoxycholic acid (DCA) on the intestinal microbiota, bile acid (BA) metabolism, and intestinal epithelium can be influenced by various factors. Depending on the specific conditions, DCA can be “bad” (proinflammatory) or “good” (anti-inflammatory). Mouse models of colitis show an increase in conjugated BAs and gut dysbiosis, including DCA-related dysbiosis, with a significant decrease in bile salt hydrolase (bsh) gene-containing taxa. Human patients with inflammatory bowel disease demonstrate, primarily, a decrease in bile acid-inducible (bai) gene-containing taxa and a deficiency in secondary BAs, suggesting their anti-inflammatory role.
| Original language | English |
|---|---|
| Pages (from-to) | 925-927 |
| Number of pages | 3 |
| Journal | Digestive Diseases and Sciences |
| Volume | 66 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Mar 2021 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords*
- Bile acids
- Deoxycholic acid
- Gut dysbiosis
- Inflammatory bowel disease
- Intestinal inflammation
- Intestinal microbiome
- Ulcerative colitis
Field of Science*
- 3.2 Clinical medicine
Publication Type*
- 1.1. Scientific article indexed in Web of Science and/or Scopus database
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