Behavioural responses of γ-MSH peptides administered into the rat ventral tegmental area

V. Klusa, S. Svirskis, B. Opmane, R. Muceniece, J. E.S. Wikberg

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

The behavioural effects induced by α-, γ1- and γ2-MSH peptides (0.3 and 3 nmole per rat) injected into the left ventral tegmental area (VTA) of rats were compared. α- and γ1-MSH caused grooming of comparable magnitude, and also additional vertical activity (rearing). By contrast γ2-MSH caused a moderate but stable catalepsy, and practically no grooming. Moreover, intra-VTA pre-treatment with γ2-MSH, 15 min prior to intra-VTA γ1-MSH, markedly attenuated both the γ1-induced grooming and vertical activities. The differences in the behavioural response of the MSH peptides indicate that they act differentially on MC receptors in the VTA.

Original languageEnglish
Pages (from-to)99-104
Number of pages6
JournalActa Physiologica Scandinavica
Volume167
Issue number2
DOIs
Publication statusPublished - 1999
Externally publishedYes

Keywords*

  • Behavioural effect
  • MSH
  • Ventral tegmental area

Field of Science*

  • 1.6 Biological sciences
  • 3.1 Basic medicine

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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