Behavioural responses of γ-MSH peptides administered into the rat ventral tegmental area

V. Klusa; S. Svirskis; B. Opmane; R. Muceniece; J. E.S. Wikberg

doi:10.1046/j.1365-201x.1999.00595.x

Behavioural responses of γ-MSH peptides administered into the rat ventral tegmental area

V. Klusa, S. Svirskis, B. Opmane, R. Muceniece, J. E.S. Wikberg

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

The behavioural effects induced by α-, γ1- and γ2-MSH peptides (0.3 and 3 nmole per rat) injected into the left ventral tegmental area (VTA) of rats were compared. α- and γ1-MSH caused grooming of comparable magnitude, and also additional vertical activity (rearing). By contrast γ2-MSH caused a moderate but stable catalepsy, and practically no grooming. Moreover, intra-VTA pre-treatment with γ2-MSH, 15 min prior to intra-VTA γ1-MSH, markedly attenuated both the γ1-induced grooming and vertical activities. The differences in the behavioural response of the MSH peptides indicate that they act differentially on MC receptors in the VTA.

Original language	English
Pages (from-to)	99-104
Number of pages	6
Journal	Acta Physiologica Scandinavica
Volume	167
Issue number	2
DOIs	https://doi.org/10.1046/j.1365-201x.1999.00595.x
Publication status	Published - 1999
Externally published	Yes

Keywords*

Behavioural effect
MSH
Ventral tegmental area

Field of Science*

1.6 Biological sciences
3.1 Basic medicine

Publication Type*

1.1. Scientific article indexed in Web of Science and/or Scopus database

Access to Document

10.1046/j.1365-201x.1999.00595.x

Cite this

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title = "Behavioural responses of γ-MSH peptides administered into the rat ventral tegmental area",

abstract = "The behavioural effects induced by α-, γ1- and γ2-MSH peptides (0.3 and 3 nmole per rat) injected into the left ventral tegmental area (VTA) of rats were compared. α- and γ1-MSH caused grooming of comparable magnitude, and also additional vertical activity (rearing). By contrast γ2-MSH caused a moderate but stable catalepsy, and practically no grooming. Moreover, intra-VTA pre-treatment with γ2-MSH, 15 min prior to intra-VTA γ1-MSH, markedly attenuated both the γ1-induced grooming and vertical activities. The differences in the behavioural response of the MSH peptides indicate that they act differentially on MC receptors in the VTA.",

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T1 - Behavioural responses of γ-MSH peptides administered into the rat ventral tegmental area

AU - Klusa, V.

AU - Svirskis, S.

AU - Opmane, B.

AU - Muceniece, R.

AU - Wikberg, J. E.S.

PY - 1999

Y1 - 1999

N2 - The behavioural effects induced by α-, γ1- and γ2-MSH peptides (0.3 and 3 nmole per rat) injected into the left ventral tegmental area (VTA) of rats were compared. α- and γ1-MSH caused grooming of comparable magnitude, and also additional vertical activity (rearing). By contrast γ2-MSH caused a moderate but stable catalepsy, and practically no grooming. Moreover, intra-VTA pre-treatment with γ2-MSH, 15 min prior to intra-VTA γ1-MSH, markedly attenuated both the γ1-induced grooming and vertical activities. The differences in the behavioural response of the MSH peptides indicate that they act differentially on MC receptors in the VTA.

AB - The behavioural effects induced by α-, γ1- and γ2-MSH peptides (0.3 and 3 nmole per rat) injected into the left ventral tegmental area (VTA) of rats were compared. α- and γ1-MSH caused grooming of comparable magnitude, and also additional vertical activity (rearing). By contrast γ2-MSH caused a moderate but stable catalepsy, and practically no grooming. Moreover, intra-VTA pre-treatment with γ2-MSH, 15 min prior to intra-VTA γ1-MSH, markedly attenuated both the γ1-induced grooming and vertical activities. The differences in the behavioural response of the MSH peptides indicate that they act differentially on MC receptors in the VTA.

KW - Behavioural effect

KW - MSH

KW - Ventral tegmental area

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DO - 10.1046/j.1365-201x.1999.00595.x

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Behavioural responses of γ-MSH peptides administered into the rat ventral tegmental area

Abstract

Keywords*

Field of Science*

Publication Type*

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