Biochemical mechanisms of mildronate action during ischemic stress

M. Dambrova, D. Daiia, E. Liepinsh, O. Kirianova, I. Kalvinsh

Research output: Contribution to journalReview articlepeer-review

3 Citations (Scopus)

Abstract

The authors in the article described biochemical mechanisms of Mildronat. The main mechanism of Mildronat activity is based on decreasing carnitine level in the organism, which leads to hampering oxidation of fatty acids. Mildronat is believed keeps on training myocardium pharmacologically even without physical activity by adapting cells to decreasing fat acids inflow and activating glucose oxidations. Under ischemic condition to obtain energy, cells use intensively glucose oxidation. Clinical studies have reliably showed Mildronat to have positive effect in treating patients with cardiovascular and ischemic cerebral diseases as well as for enhancing physical and mental efficiency.

Translated title of the contributionBiochemical mechanisms of mildronate action during ischemic stress
Original languageRussian
Pages (from-to)68-74
Number of pages7
JournalLikars'ka sprava / Ministerstvo okhorony zdorov'ia Ukraïny
Issue number2
Publication statusPublished - Mar 2004
Externally publishedYes

Field of Science

  • 3.1 Basic medicine

Publication Type

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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